TITLE

Heavy metals exposure levels and their correlation with different clinical forms of fetal growth restriction

AUTHOR(S)
Sabra, Sally; Malmqvist, Ebba; Saborit, Alicia; Gratacós, Eduard; Gomez Roig, Maria Dolores
PUB. DATE
October 2017
SOURCE
PLoS ONE;10/6/2017, Vol. 12 Issue 10, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Prenatal heavy metals exposure has shown a negative impact on birth weight. However, their influence on different clinical forms of fetal smallness was never assessed. Objectives: To investigate whether there is a differential association between heavy metals exposure and fetal smallness subclassification into intrauterine growth restriction (IUGR) and small-for-gestational age (SGA). Method: In this prospective case-control study, we included 178 mother–infant pairs; 96 of appropriate for gestational age (AGA) and 82 of small fetuses diagnosed in third trimester. The small ones were further subclassified into IUGR, n = 49 and SGA, n = 33. Cadmium (Cd), mercury (Hg), lead (Pb), arsenic (As) and zinc (Zn) levels were measured in the maternal and cord serum, and in the placentas of the three groups. Results: Maternal serum level of Cd (p<0.001) was higher in the small fetuses compared to AGA. Fetal serum level of Cd (p<0.001) was increased in the small fetuses compared to AGA. Fetal serum level of Hg (p<0.05) showed an increase in SGA compared to both IUGR and AGA. Fetal serum level of Zn was increased in the AGA (p < 0.001) compared to each of the small fetuses groups. Only differences in the levels between the small fetuses’ subgroups were detected in the fetal serum levels of Cd and Hg. Fetal birth weight was negatively correlated with the fetal serum level of Cd (p < 0.001). No differences in the placental heavy metal levels were observed among the groups. Conclusion: Fetal serum levels of Cd showed differential correlation between small fetuses' clinical subclassification, which together with the increased Cd levels in both maternal and fetal serum of the small fetuses reinforce the negative influence of heavy metals on birth weight. These findings provide more opportunities to verify the role of heavy metals exposure in relation to small fetuses’ subclassification.
ACCESSION #
125540604

 

Related Articles

  • Sorting Out the Ways to Sort Out Fetal Growth. Schulman, Joseph // Journal of Perinatology;Jul2002, Vol. 22 Issue 5, p339 

    Journal of Perinatology (2002) 22, 339–340 doi:10.1038/sj.jp.7210734

  • Uterine Artery Doppler in the Prediction of Preeclampsia and Adverse Pregnancy Outcome. Antsaklis, Aris; Daskalakis, George // Donald School Journal of Ultrasound in Obstetrics & Gynecology;Apr-Jun2010, Vol. 4 Issue 2, p117 

    Preeclampsia and fetal growth restriction are major causes of perinatal mortality and morbidity. Several studies have shown that a generalized endothelial dysfunction is associated with these complications. Clinical trials have shown that pregnant women who demonstrate high resistance in...

  • First trimester maternal serum PAPP-A levels and macrosomia in nondiabetic mothers. TARIM, Ebru; HACIVELİOĞLU, Servet Özden; ÇOK, Tayfun; BAĞIŞ, Halil Tayfun // Turkish Journal of Medical Sciences;Aug2011, Vol. 41 Issue 4, p581 

    Aim: To determine whether or not there is a relationship between first-trimester maternal serum pregnancy-associated placental protein (PAPP-A) levels and fetal macrosomia in nondiabetic mothers. Materials and methods: In this study, 63 consecutive term macrosomic neonates (Group 1) (birth...

  • Self-Reported Parental Exposure to Pesticide during Pregnancy and Birth Outcomes: The MecoExpo Cohort Study. Mayhoub, Flora; Berton, Thierry; Bach, Véronique; Tack, Karine; Deguines, Caroline; Floch-Barneaud, Adeline; Desmots, Sophie; Stéphan-Blanchard, Erwan; Chardon, Karen // PLoS ONE;Jun2014, Vol. 9 Issue 6, p1 

    The MecoExpo study was performed in the Picardy region of northern France, in order to investigate the putative relationship between parental exposures to pesticides (as reported by the mother) on one hand and neonatal parameters on the other. The cohort comprised 993 mother-newborn pairs. Each...

  • Infertility a Possible Risk Factor for Intrauterine Growth Restriction.  // Fertility Weekly;1/14/2008, p8 

    The article reports on the association between infertility and low birth weight or infants who are small for gestational age (SGA) in the U.S. and Denmark. The result of the study shows that infertility could be a risk factor for intrauterine growth restriction (IUGR) among women who have SGA...

  • An Assessment of Femur Growth Parameters in Human Fetuses and Their Relationship to Gestational Age. Ziylan, Taner; Murshid, Khalil Awadh // Turkish Journal of Medical Sciences;2003, Vol. 33 Issue 1, p27 

    Presents a study which evaluated the relationships between the crown-rump length, fetal femur growth parameters and the gestational age during the second and third trimesters of pregnancy. Design of measurements for crown-rump length; Implications of fetus' femur measurements to the calculation...

  • Comparison of adequacy of birth weight for gestational age according to different intrauterine growth curves. dos Santos Tenório, Micaely Cristina; Santos Mello, Carolina; de Farias Santos, Juliana Célia; Cabral Menezes de Oliveira, Alane // Revista Brasileira de Saude Materno Infantil;Sep-Dic2019, Vol. 19 Issue 4, p935 

    Objectives: to compare the assessment of the adequacy of birth weight for gestational age according to different intrauterine growth curves. Methods: across-sectional study, which analyzed gestational and neonatal information from 344 mother-newborn binomials. Birth weight data were analyzed...

  • Vascularity and histology of fetal labrum and chondrolabral junction: its relevance to chondrolabral detachment tears. Türker, Mehmet; Kılıçoğlu, Önder; Göksan, Bora; Bilgiç, Bilge // Knee Surgery, Sports Traumatology, Arthroscopy;Feb2012, Vol. 20 Issue 2, p381 

    Purpose: Recently, acetabular labral tears were recognized as a source of hip pain. Most of these tears were found to be localized at the chondrolabral junction. The purpose of this study was to evaluate the chondrolabral junction in reference to its collagen fiber orientation and its...

  • Curvas antropométricas de recién nacidos chilenos. ALARCÓN R., JAIME; ALARCÓN V., YASNA; HËRING A., ENRIQUE; BUCCIONI V., ROLLY // Revista Chilena de Pediatría;jul-ago2008, Vol. 79 Issue 4, p364 

    Objetivo: Design local anthropometric growth curves for selected newborns between 24 and 42 gestational weeks, in order to compare them with other intrauterine growth charts currently used in Chile Method: 86 575 infants born from single pregnancy and with the described gestational age were...

  • Third Trimester Maternal Glucose Levels From Diurnal Profiles in Nondiabetic Pregnancies. Fraser, Robert // Diabetes Care;Jun2002, Vol. 25 Issue 6, p1104 

    Presents a response to a study in which diurnal profiles performed on home blood glucose monitoring were related to sonographic parameters of fetal growth. Information on diurnal plasma glucose profiles at different gestational ages.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics