TITLE

ПРИМЕНЕНИЕ ТЕХНОЛОГИИ ТКАНЕВОЙ ИНЖЕНЕРИИ ДЛЯ ФОРМИРОВАНИЯ ХРЯЩЕВОЙ ТКАНИ ЧЕЛОВЕКА В ПРОТОЧНОМ БИОРЕАКТОРЕ

AUTHOR(S)
Севастьянов, В. И.; Басок, Ю. Б.; Григорьев, А. М.; Кирсанова, Л. А.; Василец, В. Н.
PUB. DATE
July 2017
SOURCE
Russian Journal of Transplantology & Artificial Organs;2017, Vol. 19 Issue 3, p81
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Formation of tissue-engineered construct was performed in a specially developed bioreactor. At first, a cell- engineered construct of human cartilage tissue consisting of biopolymer microstructured collagen-containing hydrogel, mesenchymal stromal cells of human adipose tissue (hADMSCs) and induction chondrogenic culture medium was prepared and placed in a perfusion bioreactor. As a result, on the 16th day of the study hADMSCs obtain a flattened shape typical for chondroblasts and demonstrate high proliferative activity with the formation of their own extracellular matrix. Histological analysis of the cultured system indicates the beginning of the formation of a tissue-engineered construct of human cartilage tissue.
ACCESSION #
125530762

 

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