Evaluation of obstructive sleep apnea in non-cystic fibrosis bronchiectasis: A cross-sectional study

Faria Júnior, Newton Santos; Urbano, Jessica Julioti; Santos, Israel Reis; Silva, Anderson Soares; Perez, Eduardo Araújo; Souza, Ângela Honda; Nascimento, Oliver Augusto; Jardim, José Roberto; Insalaco, Giuseppe; Oliveira, Luis Vicente Franco; Stirbulov, Roberto
October 2017
PLoS ONE;10/03/2017, Vol. 12 Issue 10, p1
Academic Journal
The relationship between sleep disorders and bronchiectasis has not been well described. We hypothesize that, due to the irreversible dilatation of the bronchi, the presence of secretions, and airflow obstruction, patients with non-cystic fibrosis bronchiectasis may be predisposed to hypoxemia during sleep, or to symptoms that may lead to arousal. A cross-sectional observational study was performed involving 49 patients with a clinical diagnosis of non-cystic fibrosis bronchiectasis (NCFB). All patients underwent clinical evaluation, spirometry, and polysomnography, and were evaluated for the presence of excessive daytime sleepiness (EDS) and risk of obstructive sleep apnea (OSA). The mean age of the participants was 50.3 ± 13.6 years; 51.1% of patients were male and had a mean body mass index of 23.8 ± 3.4 kg/m2. The mean total sleep time (TST) was 325.15 ± 64.22 min with a slight reduction in sleep efficiency (84.01 ± 29.2%). Regarding sleep stages, stage 1 sleep and REM sleep were abnormal. OSA was present in 40.82% of the patients. The mean arousal index was 5.6 ± 2.9/h and snoring was observed in 71.43% of the patients. The oxygen desaturation index (ODI) was 14.35 ± 15.36/h, mean minimum oxygen saturation (SpO2 nadir) was 83.29 ± 7.99%, and mean TST with an SpO2 less than 90% was 30.21 ± 60.48 min. EDS was exhibited by 53.06% of the patients and 55.1% were at high risk of developing OSA. The patients infected by Pseudomonas aeruginosa had higher apnea-hypopnea indices, ODI, and TST with SpO2 < 90%, and lower values of SpO2 nadir. Adult patients with clinically stable NCFB, especially those infected by Pseudomonas aeruginosa, display EDS and a high prevalence of OSA, associated with considerable oxygen desaturation during sleep.


Related Articles

  • CHARACTERISTICS OF TURKISH PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME. Bekci, Taha T.; Karaağaç, Güler; Karakoca, Yalçın // Nobel Medicus Journal;May-Aug2011, Vol. 7 Issue 2, p30 

    Objective: Obstructive sleep apnea syndrome (OSAS) is one of the most common sleep breathing disorders characterized by nocturnal oxygen desaturation and repeated upper airway obstruction episodes during sleep. In this study, it was aimed to assess gender specific differences in the patients...

  • Home-based diagnosis of sleep apnea.  // Internal Medicine Alert;9/29/2010 Clinical Briefs, p144 

    The article presents a study in comparing home-based diagnosis of obstructive sleep apnea (OSA) and treatment of overnight polysomnography (OPSG) for the assessment of potential OSA associated to clinical manifestations.

  • Development and validation of a questionnaire to identify patients with sleep apnea in Mexican population: Mexican questionnaire to identify sleep apnea. Romero-López, Zaira; Ochoa-Vázquez, María Dolores; Mata-Marín, José Antonio; Ochoa-Jiménez, Luis Gerardo; Rico-Méndez, Favio Gerardo // Sleep & Breathing;Jan2011, Vol. 15 Issue 1, p113 

    Purpose: To develop and validate a questionnaire to identify patients with obstructive sleep apnea (OSA) in Mexican population. Methods: We performed a cross-sectional study to develop and validate an instrument in Spanish language, consistent in an 18-item questionnaire. We enrolled patients...

  • Nocturnal hypoxemia in children and adolescents with cystic fibrosis. Trindade Ramos, Regina Terse; Pinheiro Santana, Maria Angélica; de Carvalho Almeida, Priscila; de Souza Machado Júnior, Almério; Araújo-Filho, José Bouzas; Salles, Cristina // Jornal Brasileiro de Pneumologia;nov/dez2013, Vol. 39 Issue 6, p667 

    Objective: To determine the prevalence of nocturnal hypoxemia and its association with pulmonary function, nutritional status, sleep macrostructure, and obstructive respiratory events during sleep in a population of clinically stable children and adolescents with cystic fibrosis (CF). Methods:...

  • Symptom profile of undiagnosed obstructive sleep apnoea in hypertensive outpatients in primary care: a structural equation model analysis. Broström, Anders; Sunnergren, Ola; Johansson, Peter; Svensson, Erland; Ulander, Martin; Nilsen, Per; Svanborq, Eva // Quality in Primary Care;2012, Vol. 20 Issue 4, p287 

    Background Obstructive sleep apnoea (OSA) has been linked to hypertension in sleep clinic populations, but little is known about the symptom profile of undiagnosed OSA in hypertensive outpatients in primary care. Aim To explore characteristics associated with undiagnosed OSA in hypertensive...

  • A comparative study on the clinical and polysomnographic pattern of obstructive sleep apnea among obese and non-obese subjects. Garg, Rajiv; Singh, Abhijeet; Prasad, Rajendra; Saheer, S.; Jabeed P.; Verma, Ramkishun // Annals of Thoracic Medicine;Jan-Mar2012, Vol. 7 Issue 1, p26 

    OBJECTIVE: This study was designed to compare the pattern of obstructive sleep apnea (OSA) among obese and nonobese subjects regarding clinical and polysomnographic data obtained for a polysomnographic study. METHODS: A cross.sectional retrospective descriptive study was conducted by analyzing...

  • Nocturnal hypoxemia biomarker predicts sleepiness in patients with severe obstructive sleep apnea. Uysal, Askin; Liendo, Cesar; McCarty, David; Kim, Paul; Paxson, Chad; Chesson, Andrew; Marino, Andrew // Sleep & Breathing;Mar2014, Vol. 18 Issue 1, p77 

    Purpose: This study aims to assess the association between excessive daytime sleepiness (EDS) and variables extracted from the pulse-oximetry signal obtained during overnight polysomnography. Methods: A cross-sectional design was used to study the relation between four hypoxemia variables and...

  • The Frequency of Allergic Rhinitis among Obstructive Sleep Apnea Patients: A Hospital-Based, Cross-Sectional Study. Gadi, Ghada U.; Albar, Mohammad H.; R. Fida, Abdulkareem; Sendi, Khalil S.; Alnoury, Khaled I.; Wali, Siraj O. // Journal of King Abdulaziz University: Medical Sciences;2014, Vol. 21 Issue 3, p59 

    A relationship between obstructive sleep apnea and allergic rhinitis is controversial. Allergic rhinitis may potentially worsen severity of sleep apnea and hence, treating allergic rhinitis may actually improve sleep apnea as well as habitual snoring. Our aim was to determine the prevalence of...

  • Severity of depression and anxiety in obstructive sleep apnea syndrome. Asghari, Alimohamad; Mohammadi, Fatemeh; Kamrava, Seyed; Tavakoli, Saman; Farhadi, Mohammad // European Archives of Oto-Rhino-Laryngology;Dec2012, Vol. 269 Issue 12, p2549 

    Obstructive sleep apnea (OSA) is a common sleep disorder which can result in mood problems. The aim of this study was to evaluate the severity of depression and anxiety symptoms as the most prevalent psychological disturbances present in different severity of OSA. We performed a cross-sectional...

  • Evaluation of Inflammatory Markers in a Large Sample of Obstructive Sleep Apnea Patients without Comorbidities. Bouloukaki, Izolde; Mermigkis, Charalampos; Tzanakis, Nikolaos; Kallergis, Eleftherios; Moniaki, Violeta; Mauroudi, Eleni; Schiza, Sophia E. // Mediators of Inflammation;7/31/2017, p1 

    Systemic inflammation is important in obstructive sleep apnea (OSA) pathophysiology and its comorbidity. We aimed to assess the levels of inflammatory biomarkers in a large sample of OSA patients and to investigate any correlation between these biomarkers with clinical and polysomnographic (PSG)...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics