TITLE

Selective Thermal Effects with Pulsed Irradiation from Lasers: From Organ to Organelle

AUTHOR(S)
Parrish, John A.; Anderson, R. Box; Harrist, Terrance; Paul, Barry; Murphy, George F.
PUB. DATE
June 1983
SOURCE
Journal of Investigative Dermatology;Jun83 Supplement, Vol. 80, p75s
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Specific damage by selectively absorbed, pulsed lasers can be predicted based on physical models. Thermally mediated alterations can be confined to pigmented targets from the level of subcellular organelles (e.g., melanosomes) to large multicellular tissue structures (e.g., blood vessels) by the appropriate manipulation of wave-length and pulse duration. Highly selective damage to human cutaneous microvessels in vivo is shown to occur after 0.3-μs 577-nm dye laser pulses; the epidermis and dermal structures other than vessels are spared. Observations in an animal model suggest that hemorrhage or, at lower doses, selective intravascular coagulation and permanent microvascular hemostasis occur. Highly selective damage to melanized cells and to single melanosomes in situ was shown to occur after single 20-ns 351-nm pulses from a XeF excimer laser, Basal-cell- and melanocyte-specific necrosis is followed by gross hypopigmentation. In this case there is no evidence of vascular damage. The most likely modes of selective alterations include localized thermal denaturation, vaporization, and shock-wave generation. Means of predicting and controlling histologically selective radiant heating effects in skin are suggested.
ACCESSION #
12537266

 

Related Articles

  • Scanning and Transmission Electron Microscope Study on the Terminal Blood Vessels of the Rat Skin. Imayama, Shuhei // Journal of Investigative Dermatology;Mar1981, Vol. 76 Issue 3, p151 

    The microvasculature in the subepidermal layer of the rat foot was examined by scanning electron microscopy of corrosion casts and by transmission electron microscopy of serial ultrathin sections. Three-dimensional observation of the casts demonstrated that, in the walking pads (pressure areas)...

  • DEMONSTRATION AND CHARACTERIZATION OF AN EPIDERMAL ANGIOGENIC FACTOR. Wolf Jr., John E.; Harrison, Ray G. // Journal of Investigative Dermatology;Sep73, Vol. 61 Issue 3, p130 

    In this study the vasoproliferative effects of adult hamster epidermis and epidermal homogenates on the microvasculature of the hamster cheek pouch were observed. Implants of epidermis stimulated a rapid growth of new vessels both upon direct implantation and when separated from the vascular bed...

  • A new Monte Carlo program for simulating light transport through Port Wine Stain skin. Lister, T.; Wright, P.; Chappell, P. // Lasers in Medical Science;May2014, Vol. 29 Issue 3, p1017 

    A new Monte Carlo program is presented for simulating light transport through clinically normal skin and skin containing Port Wine Stain (PWS) vessels. The program consists of an eight-layer mathematical skin model constructed from optical coefficients described previously. A simulation...

  • Blood loss measurement with use of pneumoperitoneum when harvesting split-thickness skin grafts in the abdominal region. Kiliç, Azize; Varo&gcaron;lu, E.; Kiliç, A. // European Journal of Plastic Surgery;Aug2001, Vol. 24 Issue 4, p192 

    Reconstruction of extensive skin defects may present difficulty due to a shortage of donor sites. Surgeons often face this problem in grafting large skin defects of the extremities, where it may be necessary to use abdominal, thoracic, lumbar, or scalp skin for reconstruction. For anatomical...

  • THE LASER'S EDGE. Winter, Jessica // O, The Oprah Magazine;Oct2008, Vol. 9 Issue 10, p268 

    A personal narrative is presented which explores the author's experience of finding solutions to pale skin.

  • dermovascular.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p620 

    A definition of the term "dermovascular," which refers to the skin and its blood vessels, is presented.

  • Infantile systemic lupus erythematosus presenting with pulmonary hemorrhage. Kreindler, James; Ellis, Demetrius; Vats, Abhay; Kurland, Geoffrey; Ranganathan, Sarangarajan; Moritz, Michael // Pediatric Nephrology;Apr2005, Vol. 20 Issue 4, p522 

    Systemic lupus erythematosus in infants born to healthy mothers is a rare entity. We describe a male infant who presented at 1 month of age with pulmonary hemorrhage and glomerulonephritis due to systemic lupus erythematosus, confirmed serologically and histologically. He was managed with a...

  • Laser optical method of visualizing cutaneous blood vessels and its applications in biometry and photomedicine. Asimov, M.; Asimov, R.; Rubinov, A. // Optics & Spectroscopy;May2011, Vol. 110 Issue 5, p823 

    We propose and examine a new approach to visualizing a local network of cutaneous blood vessels using laser optical methods for applications in biometry and photomedicine. Various optical schemes of the formation of biometrical information on the architecture of blood vessels of skin tissue are...

  • Telangiectasis in CREST syndrome and systemic sclerosis: correlation of clinical and pathological features with response to pulsed dye laser treatment. Halachmi, Shlomit; Gabari, Osama; Cohen, Sarit; Koren, Romelia; Amitai, Dan; Lapidoth, Moshe // Lasers in Medical Science;Jan2014, Vol. 29 Issue 1, p137 

    Telangiectasia are cardinal features of systemic sclerosis (SS) and calcinosis, Raynaud's syndrome, esophageal motility, sclerodactyly, telangiectasias (CREST) syndrome. The etiology of telangiectasia in these syndromes is unknown, but vascular dysfunction has been proposed. However, the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics