Epidermal Lipids, Barrier Function, and Desquamation

Elias, Peter M.
June 1983
Journal of Investigative Dermatology;Jun83 Supplement, Vol. 80, p44s
Academic Journal
Based on recent morphologic, histochemical, and biochemical data, we propose a heterogeneous two-compartment model of the stratum corneum that ascribes a special role for intercellular lipids in the regulation of stratum corneum barrier function and desquamation. The evidence in favor of the model and several predictions based on the model are surveyed in this review.


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