Regulation of Gelatinase in Human Skin Organ Cultures by Glucocorticoids

Seltzer, Jo Louise; Horan, Thomas P.; Eisen, Arthur Z.
June 1983
Journal of Investigative Dermatology;Jun83 Supplement, Vol. 80, p42s
Academic Journal
Hydrocortisone and dexamethasone prevent the appearance of gelatinase in serum-free explant cultures of normal human skin. Hydrocortisone inhibits maximally at 10-6 M and dexamethasone at 10-8 M in culture medium, Glucocorticoids at these concentrations do not cause a generalized decrease in protein synthesis; thus the effect on gelatinase shows specificity. The reduction in gelatinase activity caused by dexamethasone can be overcome in the presence of dexaniethasone 21-mesylate, a glucocorticoid antagonist that binds Irreversibly to the cytoplasmic steroid receptors These data suggest that the enzymes of collagen degradation, collagenase and gelatinase, may be coregulated.


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