Treatment with Piperacillin-Tazobactam and False-Positive Aspergillus Galactomannan Antigen Test Results for Patients with Hematological Malignancies

Adam, Olivier; Aupérin, Anne; Wilquin, Fanny; Bourhis, Jean-Henri; Gachot, Bertrand; Chachaty, Elisabeth
March 2004
Clinical Infectious Diseases;3/15/2004, Vol. 38 Issue 6, p917
Academic Journal
We report the occurrence of a high rate of false-positive test results during the surveillance of hematology patients for galactomannan (GM) antigenemia. Among 218 patients surveyed from June 2002 through June 2003, 42 (19.3%) had ≥1.5). serum sample positive for GM (optical density index, >1.5). Of these patients, 38 had no additional evidence of invasive aspergillosis, and, therefore, their test results were considered to be false-positives. Case-control analysis showed that treatment with piperacillin-tazobactam was the only risk factor significantly associated with receiving false-positive test results. When tested for GM antigen, 3 of 4 piperacillin-tazobactam batches had positive results. Physicians should be aware of the possible interference of treatment with piperacillin-tazobactam when interpreting the results of the GM assay.


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