September 1976
Journal of Investigative Dermatology;Sep76, Vol. 67 Issue 3, p477
Academic Journal
One issue relates to the in vitro assays for transfer factor, since a reproducible and sensitive assay of this material is absolutely essential to its ultimate definition. It would also be important to return to a consideration of the mechanism by which lymphocyte activation elicits fibrin deposition, especially in view of the fact that the deposition of fibrin appears to be different in a delayed-type hypersensitivity reaction than in immune complex lesions. It is peculiar that the guinea pig that has been the standard animal for studying delayed hypersensitivity, appears to be a very poor animal for studying transfer factor.


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