Kantor, Fred S.; Dwyer, John M.; Mangi, Richard J.
September 1976
Journal of Investigative Dermatology;Sep76, Vol. 67 Issue 3, p470
Academic Journal
Sarcoidosis has been recognized as a disease with immunologic features for almost 60 years and yet, the exact nature of immunologic malfunction remains controversial. Almost any lymph node, even if it appears normal, is likely to contain characteristic noncaseating granulomata. Depression of skin reactivity to antigens which have been known to produce delayed hypersensitive reactions in normal persons is not a universal feature of the disease. Paradoxically, a granulomatous response to Kveim antigen is often observed; however, the time course and histologic characteristics make it difficult to classify this reaction with other delayed-type hypersensitivity reactions.


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