Franklin, Edward C.
September 1976
Journal of Investigative Dermatology;Sep76, Vol. 67 Issue 3, p451
Academic Journal
Amyloidosis is widely distributed in the animal kingdom. The clinical features of this disorder are a consequence of the destruction and replacement of vital organs by the extracellular deposition of a proteinaceous substance known as amyloid. Hence, it is not surprising that recent biochemical and immunologic studies of amyloid substance have provided strong support for the clinical impression that amyloidosis may be a term that encompasses a variety of different disorders. Amyloidosis is relatively rare as a clinically significant disease. Nevertheless, because of its varied manifestations, its frequent association with a number of diseases involving the immune system, and the deposition of amyloid as part of the aging process.


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