TITLE

CUTANEOUS T-CELL LYMPHOMAS: CLUES OF A SKIN THYMUS INTERACTION

AUTHOR(S)
Edelson, Richard L.
PUB. DATE
September 1976
SOURCE
Journal of Investigative Dermatology;Sep76, Vol. 67 Issue 3, p419
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The term "cutaneous lymphomas" refers to those lymphoproliferative disorders characterized by widespread and perhaps primary skin involvement. In the investigation of lymphoproliferative disorders, the cellular immunologist has four broad objectives: first, identification of common membrane and functional properties of the neoplastic cells; second, recognition of distinguishing features of the neoplastic cells; third, identification of certain of the manifestations of the lymphomas that might be neoplastic amplifications of normal phenomena and finally, acquisition of large homogeneous populations of lymphocytes.
ACCESSION #
12514718

 

Related Articles

  • Use of the alkaline in vivo Comet assay for mechanistic genotoxicity investigations. Andreas Hartmann; Martin Schumacher; Ulla Plappert-Helbig; Phil Lowe; Willi Suter; Lutz Mueller // Mutagenesis;Jan2004, Vol. 19 Issue 1, p51 

    The alkaline Comet assay was used to investigate the in vivo genotoxicity of 17 compounds. Altogether 21 studies were conducted with these compounds. The investigations were triggered for various reasons. The main reason for performing the studies was to evaluate the in vivo relevance of in...

  • In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3. Sommer, V.H.; Clemmensen, O.J.; Nielsen, O.; Wasik, M.; Lovato, P.; Brender, C.; Eriksen, K.W.; Woetmann, A.; Kaestel, C.G.; Nissen, M.H.; Ropke, C.; Skov, S.; Ødum, N. // Leukemia (08876924);Jul2004, Vol. 18 Issue 7, p1288 

    A characteristic feature of neoplastic transformation is a perpetual activation of oncogenic proteins. Here, we studied signal transducers and activators of transcription (STAT) in patients with mycosis fungoides (MF)/cutaneous T-cell lymphoma (CTCL). Malignant lymphocytes in dermal infiltrates...

  • The particular relationship between Parkinson’s disease and malignancy: a focus on skin cancers. Inzelberg, Rivka; Israeli-Korn, Simon D. // Journal of Neural Transmission;Nov2009, Vol. 116 Issue 11, p1503 

    Although the risk for most cancers appears to be relatively low in patients with Parkinson’s disease (PD), skin cancers and melanomas occur more frequently in the PD population as compared to controls. This article summarizes the findings of cohort studies on skin cancer in...

  • Contrasting effects of proinflammatory and T-helper lymphocyte subset-2 cytokines on the 5-lipoxygenase pathway in monocytes. Nassar, George M.; Montero, Angel; Fukunaga, Megumu; Badr, Kamal F. // Kidney International;May1997, Vol. 51 Issue 5, p1520 

    Human peripheral blood monocytes (HPBMs) express 5-lipoxygenase (5-LO) and 5-LO activating protein (FLAP), and hence have an ability to synthesize proinflammatory leukotrienes (LTs). Regulation of 5-LO and FLAP expression is a major determinant of cellular LT synthesis. We examined the effects...

  • Leukocyte Function-Associated Antigen-3 (LFA-3). Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p384 

    An entry for "leukocyte function-associated antigen-3 (LFA-3)" is presented. It refers to a co-stimulatory molecule whose ligand is the CD2 molecule expressed on T lymphocytes. LFA-3 is involved in cytokine secretion.

  • MORFOLOÅ KE I EPIDEMIOLOÅ KE OSOBINE HODGKIN-OVOG LIMFOMA. Čičkušić, Elmir; Mustedanagić-Mujanović, Jasminka; Iljazović, Ermina; Karasalihović, Zinaida // Acta Medica Saliniana;2007, Vol. 36 Issue 2, p117 

    Introduction: Hodgkin's lymphoma is a neoplastic proliferation of Reed-Sternberg's cells and their variants. After more than 170 years from the first description of this lymphoma, it continuously arouses attention of clinicians, diagnosticians and scientists, because of its characteristic...

  • Superantigens Increase the Survival of Mice Bearing T Cell Lymphomas by Inducing Apoptosis of Neoplastic Cells. Mundiñano, Juliana; Berguer, Paula M.; Cabrera, Gabriel; Lorenzo, Daniela; Nepomnaschy, Irene; Piazzon, Isabel // PLoS ONE;2010, Vol. 5 Issue 12, p1 

    Superantigens bind to major histocompatibility complex class II molecules and interact with T cells expressing a particular T cell receptor Vb inducing a strong proliferation/deletion response of the superantigen-reactive T cells. However, there have been no attempts to investigate the ability...

  • Mucous membrane plasmacytosis of the nose in a patient affected by B-cell chronic lymphocytic leukemia. Garzaro, Massimiliano; Pecorari, Giancarlo; Pezzoli, Matteo; Arrondini, Marisa; Novero, Domenico; Nadalin, Juri; Giordano, Carlo // European Archives of Oto-Rhino-Laryngology;Oct2009, Vol. 266 Issue 10, p1651 

    Mucous membrane plasmacytosis (MMP) is a rare idiopathic condition characterized by infiltration of the mucosa by non neoplastic plasma cells. In this report we describe a case of mucous membrane plasmacytosis of the nose in a 72-year-old woman patient affected by B-cell chronic lymphocytic...

  • Prognostic Impact of Lymphocytes in Soft Tissue Sarcomas. Sorbye, Sveinung W.; Kilvaer, Thomas; Valkov, Andrej; Donnem, Tom; Smeland, Eivind; Al-Shibli, Khalid; Bremnes, Roy M.; Busund, Lill-Tove // PLoS ONE;2011, Vol. 6 Issue 1, p1 

    Purpose: The purpose of this study was to clarify the prognostic significance of lymphocyte infiltration in soft tissue sarcomas (STS). Prognostic markers in potentially curable STS should guide therapy after surgical resection. The immune status at the time of resection may be important, but...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics