TITLE

IMMUNOCHEMISTRY AND IMMUNOBIOLOGY OF THE COMPLEMENT SYSTEM

AUTHOR(S)
Gigli, Irma
PUB. DATE
September 1976
SOURCE
Journal of Investigative Dermatology;Sep76, Vol. 67 Issue 3, p346
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The complement system, a complex mixture of at least 15 sequentially activated plasma proteins, constitutes one of the primary effector systems of immunologically induced inflammatory reactions. The products and byproducts of complement activation have distinct biologic significance. They mediate structural and functional alterations of cellular membranes and activation of specific cellular functions. The proteins are present in plasma in nonactivated form. Activation is by a series of specific proteolytic reactions, which can be initiated by antigen-antibody complexes, fungal and bacterial substances.
ACCESSION #
12514703

 

Related Articles

  • Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Rooijakkers, Suzan H. M.; Jin Wu; Ruyken, Maartje; van Domselaar, Robert; Planken, Karel L.; Tzekou, Apostolia; Ricklin, Daniel; Lambris, John D.; Janssen, Bert J. C.; van Strijp, Jos A. G.; Gros, Piet // Nature Immunology;Jul2009, Vol. 10 Issue 7, p721 

    Activation of the complement system generates potent chemoattractants and leads to the opsonization of cells for immune clearance. Short-lived protease complexes cleave complement component C3 into anaphylatoxin C3a and opsonin C3b. Here we report the crystal structure of the C3 convertase...

  • ENGINEERING OF MICROBIAL PROTEASES: IMPROVING STABILITY AND CATALYTIC PERFORMANCES. Mienda, Bashir Sajo; Yahya, Adibah // IIOAB Journal;Nov/Dec2011, Vol. 2 Issue 8, p10 

    Proteolytic enzymes are becoming more ubiquitous as bacteria and fungi. Some proteases from microbial sources are industrially important enzymes but often have to be improved for their catalytic efficiency and stabilities in solvents and temperature at industrial scales in order to suit their...

  • Degradation of proteinaceous substrates by xylotrophic basidiomycetes. Dunaevsky, Ya. E.; Dong Zhang; Matveeva, A. R.; Belyakova, G. A.; Belozersky, M. A. // Microbiology (00262617);Jan2006, Vol. 75 Issue 1, p35 

    The ability of various xylotrophs to produce extracellular proteolytic enzymes has been studied, with emphasis on medium-related factors regulating their secretion. Direct measurement of proteolytic activity in the culture liquid and postelectrophoresis determination of protease activity in...

  • The Role of Complement in Periodontal Diseases. Schenkein, Harvey A. // Critical Reviews in Oral Biology & Medicine;1991, Vol. 2 Issue 1, p65 

    The complement system has been implicated as both a pathogenic mechanism and a means of protection in periodontal diseases. It is well known that bacteria activate complement; such activation can initiate a number of events, including bacterial opsonization and killing, release of inflammatory...

  • Synthesis of Peptide Amides using Sol-Gel Immobilized Alcalase in Batch and Continuous Reaction System. Corîci, L. N.; Frissen, A. E.; Van Zoelen, D -J.; Eggen, I. F.; Peter, F.; Davidescu, C. M.; Boeriu, C. G. // World Academy of Science, Engineering & Technology;Apr2011, Issue 52, p361 

    Two commercial proteases from Bacillus licheniformis (Alcalase 2.4 L FG and Alcalase 2.5 L, Type DX) were screened for the production of Z-Ala-Phe-NH2 in batch reaction. Alcalase 2.4 L FG was the most efficient enzyme for the C-terminal amidation of Z-Ala-Phe-OMe using ammonium carbamate as...

  • Antibody production with yeasts and filamentous fungi: on the road to large scale? Gasser, Brigitte; Mattanovich, Diethard // Biotechnology Letters;Feb2007, Vol. 29 Issue 2, p201 

    Yeasts and filamentous fungi have gained significant interest for the production of recombinant antibodies and antibody fragments. The opportunities and constraints of antibody (fragment) production in these hosts are highlighted as well as cell engineering strategies to overcome the...

  • Optimization of Protein Secretion by Bacillus subtilis. Nijland, Reindert; Kuipers, Oscar P. // Recent Patents on Biotechnology;Jun2008, Vol. 2 Issue 2, p79 

    The gram-positive bacterium Bacillus subtilis is widely known for its capacity to produce and secrete large amounts of industrially relevant proteins, mostly endogenous enzymes like proteases and lipases. The use of B. subtilis has many advantages, such as its GRAS status and the easy and...

  • Furin Cleavage of Bacterial Expressed Glutathione-S-Transferase-Pro-Transforming Growth Factor β1 Fusion Protein In Vitro. Kahle, N. A.; Joffroy, C.; Popp, S. L.; Knabbe, C.; Stope, M. B. // Protein & Peptide Letters;Apr2010, Vol. 17 Issue 4, p416 

    To investigate the processing of transforming growth factor β1 (TGFβ1) pro-protein by furin protease we expressed a GST-pro-TGFβ1 fusion protein in bacteria. Analysis of the furin digestion pattern revealed the liberation of 12.5 kDa TGFβ1 monomers. There was no evidence for cleavage...

  • Exocellular Peptides from Antarctic Psychrophile Pseudoalteromonas Haloplanktis. Mitova, Maya; Tutino, Maria Luisa; Infusini, Giuseppe; Marino, Gennaro; De Rosa, Salvatore // Marine Biotechnology;Sep/Oct2005, Vol. 7 Issue 5, p523 

    A novel diketopiperazine, named cyclo-( D-pipecolinyl- L-isoleucine) (DKP 1), and 7 known diketopiperazines were isolated from the cell-free culture supernatant of the Antarctic psychrophilic bacterium Pseudoalteromonas haloplanktis TAC125. Two diketopiperazines containing pipecolinyl moiety...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics