McDevitt, Hugh O.
September 1976
Journal of Investigative Dermatology;Sep76, Vol. 67 Issue 3, p320
Academic Journal
The purpose of this review is to outline the current knowledge of the genetic regulation of the immunoglobulin IgE antibody response. This response is governed in part by specific immune response (Ir) genes, which determine the ability to respond well or poorly to specific antigens. Definitive evidence for localization of specific Ir genes in man has not yet been achieved. However, based on evidence obtained in the rhesus monkey, Ir genes in primates appear to map along with the antigens eliciting the mixed lymphocyte culture reaction and outside the two loci coding for the major, serologically detected, ubiquitous major transplantation antigens.


Related Articles

  • Characterisation of mouse monoclonal antibodies against rhesus macaque killer immunoglobulin-like receptors KIR3D. Hermes, Meike; Weil, Sandra; Groth, Ariane; Dressel, Ralf; Koch, Joachim; Walter, Lutz // Immunogenetics;Nov2012, Vol. 64 Issue 11, p845 

    Killer immunoglobulin-like receptors (KIRs) represent a highly polymorphic and diverse gene family in rhesus macaques. Analyses of the respective gene products have been hampered until now due to non-availability of specific monoclonal antibodies and failure of cross-reactivity of anti-human KIR...

  • B-cell responses: Revising autoantibody responses. Allen, Sarah // Nature Reviews Immunology;Sep2008, Vol. 8 Issue 9, p660 

    The article provides information on the result of the study regarding the expression of recombination activating gene (RAG) proteins in peripheral B cells in the bone marrow which was published in the "Journal of Clinical Investigation." It states that the re-expression of RAG proteins enables...

  • HLA-DRB1 May Be Antagonistically Regulated by the Coordinately Evolved Promoter and 39-UTR under Stabilizing Selection. Benrong Liu; Yonggui Fu; Zhifen Wang; Sisi Zhou; Yu Sun; Yuping Wu; Anlong Xu // PLoS ONE;2011, Vol. 6 Issue 10, p1 

    HLA-DRB1 is the most polymorphic MHC (major histocompatibility complex) class II gene in human, and plays a crucial role in the development and function of the immune system. Extensive polymorphisms exist in the promoter and 3'-UTR of HLADRB1, especially a LTR (Long terminal repeat) element in...

  • MicroRNA profiling of rhesus macaque embryonic stem cells. Zhenghua Sun; Qiang Wei; Yanfeng Zhang; Xiechao He; Weizhi Ji; Bing Su // BMC Genomics;2011, Vol. 12 Issue 1, p276 

    Background: MicroRNAs (miRNAs) play important roles in embryonic stem cell (ESC) self-renewal and pluripotency. Numerous studies have revealed human and mouse ESC miRNA profiles. As a model for human-related study, the rhesus macaque is ideal for delineating the regulatory mechanisms of miRNAs...

  • Minimal Effect of Ectopic Gene Conversion Among Recent Duplicates in Four Mammalian Genomes. McGrath, Casey L.; Casola, Claudio; Hahn, Matthew W. // Genetics;Jun2009, Vol. 182 Issue 2, p615 

    Gene conversion between duplicated genes has been implicated in homogenization of gene families and reassortment of variation among paralogs. If conversion is common, this process could lead to errors in gene tree inference and subsequent overestimation of rates of gene duplication. After...

  • Comprehensive survey of human brain microRNA by deep sequencing. Ning-Yi Shao; Hai Yang Hu; Zheng Yan; Ying Xu; Hao Hu; Menzel, Corinna; Na Li; Wei Chen; Khaitovich, Philipp // BMC Genomics;2010, Vol. 11, p409 

    Background: MicroRNA (miRNA) play an important role in gene expression regulation. At present, the number of annotated miRNA continues to grow rapidly, in part due to advances of high-throughput sequencing techniques. Here, we use deep sequencing to characterize a population of small RNA...

  • Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion. Bogers, Willy M.; Oostermeijer, Herman; Mooij, Petra; Koopman, Gerrit; Verschoor, Ernst J.; Davis, David; Ulmer, Jeffrey B.; Brito, Luis A.; Cu, Yen; Banerjee, Kaustuv; Otten, Gillis R.; Burke, Brian; Dey, Antu; Heeney, Jonathan L.; Shen, Xiaoying; Tomaras, Georgia D.; Labranche, Celia; Montefiori, David C.; Liao, Hua-Xin; Haynes, Barton // Journal of Infectious Diseases;Mar2015, Vol. 211 Issue 6, p947 

    Self-amplifying messenger RNA (mRNA) of positive-strand RNA viruses are effective vectors for in situ expression of vaccine antigens and have potential as a new vaccine technology platform well suited for global health applications. The SAM vaccine platform is based on a synthetic,...

  • Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic—pituitary—adrenal axis function and in vitro gene expression. Chen, G.-L.; Novak, M. A.; Hakim, S.; Xie, Z.; Miller, G. M. // Molecular Psychiatry;Oct2006, Vol. 11 Issue 10, p914 

    Tryptophan hydroxylase-2 (TPH2) is a newly identified second form of TPH responsible for serotonin synthesis in the brain and has been increasingly implicated as a contributor to the etiology of various psychiatric disorders. In this study, we have identified the constellation of polymorphisms...

  • κMicroarray analysis of relative gene expression stability for selection of internal reference genes in the rhesus macaque brain. Noriega, Nigel C.; Kohama, Steven G.; Urbanski, Henryk F. // BMC Molecular Biology;2010, Vol. 11, p47 

    Background: Normalization of gene expression data refers to the comparison of expression values using reference standards that are consistent across all conditions of an experiment. In PCR studies, genes designated as "housekeeping genes" have been used as internal reference genes under the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics