TITLE

GENETIC CONSIDERATIONS IN ATOPIC AND OTHER DERMATOLOGIC CONDITIONS

AUTHOR(S)
McDevitt, Hugh O.
PUB. DATE
September 1976
SOURCE
Journal of Investigative Dermatology;Sep76, Vol. 67 Issue 3, p320
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The purpose of this review is to outline the current knowledge of the genetic regulation of the immunoglobulin IgE antibody response. This response is governed in part by specific immune response (Ir) genes, which determine the ability to respond well or poorly to specific antigens. Definitive evidence for localization of specific Ir genes in man has not yet been achieved. However, based on evidence obtained in the rhesus monkey, Ir genes in primates appear to map along with the antigens eliciting the mixed lymphocyte culture reaction and outside the two loci coding for the major, serologically detected, ubiquitous major transplantation antigens.
ACCESSION #
12514350

 

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