TITLE

THE DIVERSITY OF MAST CELL-DERIVED MEDIATORS: IMPLICATIONS FOR ACUTE, SUBACUTE, AND CHRONIC CUTANEOUS INFLAMMATORY DISORDERS

AUTHOR(S)
Soter, Nicholas A.; Austen, K. Frank
PUB. DATE
September 1976
SOURCE
Journal of Investigative Dermatology;Sep76, Vol. 67 Issue 3, p313
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The consequences of uncontrolled mast cell activation include both an acute pharmacologic phase related to the release of factors that increase vascular permeability and constrict smooth muscle and a subacute inflammatory phase related to the specific recruitment by mediators of polymorphonuclear leukocytes and the activation of platelets. In addition, uncontrolled mast cell activation could proceed to a self-perpetuating inflammatory state. Human lung obtained from allergic individuals releases histamine, slow reacting substance of anaphylaxis and eosinophil chemotactic factor of anaphylaxis upon challenge with specific allergen.
ACCESSION #
12514349

 

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