TITLE

GENETIC DISORDERS - DEVELOPMENT A functional immature model of chronic partial ureteral obstruction

AUTHOR(S)
Beharrie, Ashraf; Franc-Guimond, Julie; Rodriguez, Maria M.; Au, Jason; Zilleruelo, Gastón; Abitbol, Carolyn L.
PUB. DATE
April 2004
SOURCE
Kidney International;Apr2004, Vol. 65 Issue 4, p1155
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A functional immature model of chronic partial ureteral obstruction. Background. The most common nonlethal congenital anomaly of the urinary tract is ureteral obstruction without dysplasia. Although rarely progressive, the morbidity associated with metabolic and surgical management is considerable. Our study was designed to measure local and systemic pathophysiologic mechanisms in an immature model of chronic partial unilateral ureteral obstruction (UUO) after completion of glomerulogenesis. Methods. A partial UUO was created by the method of “psoas wrap” in young male weanling rats. Control animals were sham operated. Three groups were divided as follows: sham ( N= 15), UUO ( N= 18), and UUO + angiotensin-converting enzyme (ACE) ( N= 16) inhibitor, enalapril. Renal glomerular and tubular functions were determined by creatinine and uric acid clearances. Diuresis was assessed by urine volume, osmolality, and fractional solute excretions from samples above and below the obstruction. Proteinuria was determined by the urine protein/creatinine ratio (Up/c). Results. Proteinuria was attenuated in UUO + ACE-treated animals. The hyperuricemia of the immature UUO animals was avoided by an increase in the clearance of uric acid in the UUO + ACE-treated group. Fractional solute excretions suggested a diversion of diuresis to the contralateral unobstructed kidney. Conclusion. Angiotensin blockade during chronic UUO in young rats affords protection by attenuating proteinuria, promoting uricosuria, and diverting solute diuresis. These data suggest a complex interaction of local and systemic mechanisms unique to the maturing kidney.
ACCESSION #
12472472

 

Related Articles

  • Gout.  // Encyclopedic Reference of Molecular Pharmacology;2004, p428 

    A definition of the term "gout" is presented. It refers to the consequence of hyperuricemia and is characterized by uric acid deposits in joints, bursae, tendons, kidney and urinary tract. It is characterized by asymptomatic hyperuricemia in the initial stage. It describes the second, third and...

  • hyperuricemia.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1128 

    A definition of the term "hyperuricemia," which refers to an excessive amount of uric acid in the blood, is presented.

  • Increase in Serum Uric Acid Is Selectively Associated With Stroke in Type 2 Diabetes. Seghieri, Giuseppe; Moruzzo, Daniela; Fascetti, Stefano; Bambini, Clio; Anichini, Roberto; de Bellis, Alessandra; Alviggi, Lorenzo; Franconi, Flavia // Diabetes Care;Jun2002, Vol. 25 Issue 6, p1095 

    Discusses the association of the increase in serum uric acid with stroke in type 2 diabetes. Description of hyperuricemia; Discussion on transient ischemic attack; Analysis of the findings.

  • Gout without hyperuricemia. McCarty, Daniel J. // JAMA: Journal of the American Medical Association;1/26/94, Vol. 271 Issue 4, p302 

    Illustrates the diagnostic and therapeutic misadventures that can occur when acute gout is not considered because of normal uric acid levels. Explanation of pathophysiologic characteristics underlying urate crystal deposition; Physicochemical properties of sodium urate; Definition of...

  • Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. LECOULTRE, VIRGILE; EGLI, LÉONIE; THEYTAZ, FANNY; DESPLAND, CAMILLE; SCHNEITER, PHILIPPE; TAPPY, LUC // Diabetes Care;Sep2013, Vol. 36 Issue 9, pe149 

    A letter to the editor is presented discussing the association between fructose-induced hyperuricemia with a decreased renal uric acid excretion in humans.

  • Hyperuricemia Possibly Linked to Hematospermia. FREI, ROSEMARY // Renal & Urology News;Jan2014, Vol. 13 Issue 1, p21 

    The article focuses on a study conducted by the researchers from Egypt which suggests the possible association of hematospermia to hyperuricemia.

  • uric acid.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p2410 

    An encyclopedia entry for "uric acid" is presented, which refers to a crystalline acid, an end product of purine metabolism and a common constituent of urinary stones and gouty tophi.

  • Hyperuricemia and its related factors in an urban population, Izmir, Turkey. Sari, Ismail; Akar, Servet; Pakoz, Betul; Sisman, Ali Riza; Gurler, Oguz; Birlik, Merih; Onen, Fatos; Akkoc, Nurullah // Rheumatology International;Jun2009, Vol. 29 Issue 8, p869 

    The aim of this study was to examine the prevalence of hyperuricemia and its associated factors in an urban area of Izmir, located in western Turkey. Our study group was selected by computerized sampling from the participants of a larger population-based study searching for the prevalence of...

  • Correspondence. Samanta, Debopam; Mishra, Devendra; Nikunj, Niraj; Sertoglu, Erdim; Stelmach, Marian; Wasilewska, Anna; Ansary, Althaf; Pothapregada, Sriram; Kaul, Kanwar // Indian Pediatrics;Jul2015, Vol. 52 Issue 7, p623 

    Several letters to the editor are presented related to medical topics including reader's appreciation to the publication of article regarding epileptic syndrome, the cause nuclear gaze palsy, and the evaluation of serum uric acid in adolescents with hyperuricemia.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics