NEPHROLOGY FORUM The intrarenal renin-angiotensin system in hypertension

Navar, L. Gabriel
April 2004
Kidney International;Apr2004, Vol. 65 Issue 4, p1522
Academic Journal
A 50-year-old woman with type 2 diabetes melitus and hypertension was admitted to Brigham and women's Hospital in Boston for entry into a clinical research protocol involving hemodynamic responses to angiotensin II receptor blockade. The medical history is significant for hypertriglyceridemia and asthma. Physical examination revealed that the patient was morbidly obese and her abdomen was soft; bowel sounds were present. The complex and extensive actions of angiotensin receptors on renal function are mediated by the widespread distribution of angiotensin II receptors throughout the kidney in nephron segments.


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