TITLE

Interferon Gamma Is a Marker for Histiocytosis X Cells in the Skin

AUTHOR(S)
Neumann, Christine; Schaumburg-Lever, Gundula; Döpfer, Roland; Kolde, Gerhard
PUB. DATE
September 1988
SOURCE
Journal of Investigative Dermatology;Sep88, Vol. 91 Issue 3, p280
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In histiocytosis X (HX), which is regarded as a proliferative disease of Langerhans cells (LCs), the tumor cells share characteristic membrane antigens and ultrastructural features with normal LCs. To the present no markers have been described which distinguish HX cells from normal epidermal LCs. Here we report on the selective reactivity of HX cells with a monoclonal antibody against interferon gamma (IFNg). Our results show that HX cells share an epitope with human IFNg while normal LCs do not. It remains to be established whether the expression of IFNg is specific for HX cells or rather characterizes a certain activation state of LCs.
ACCESSION #
12470470

 

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