Predictors of the Incident Metabolic Syndrome in Adults

Palaniappan, Latha; Carnethon, Mercedes R.; Wang, Yun; Hanley, Anthony J. G.; Fortmann, Stephen P.; Haffner, Stephen M.; Wagenknecht, Lynne
March 2004
Diabetes Care;Mar2004, Vol. 27 Issue 3, p788
Academic Journal
To prospectively investigate predictors of the incident metabolic syndrome in nondiabetic adults. The best predictors of incident metabolic syndrome were waist circumference (odds ratio [OR] 1.7 [1.3–2.0] per 11 cm), HDL cholesterol (0.6 [0.4–0.7] per 15 mg/dl), and proinsulin (1.7 [1.4–2.0] per 3.3 pmol/1). Signal detection analysis identified waist circumference (>89 cm in women, >102 cm in men) as the optimal predictor. These findings suggest that obesity may precede the development of other metabolic syndrome components. Interventions that address obesity and reduce waist circumference may reduce the incidence of the metabolic syndrome in nondiabetic adults.


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