A Danish Diabetes Risk Score for Targeted Screening

Glümer, Charlotte; Carstensen, Bendix; Sandbæk, Annelli; Lauritzen, Torsten; Jørgensen, Torben; Borch-Johnsen, Knut
March 2004
Diabetes Care;Mar2004, Vol. 27 Issue 3, p727
Academic Journal
To develop a simple self-administered questionnaire identifying individuals with undiagnosed diabetes with a sensitivity of 75 % and minimizing the high-risk group needing subsequent testing. The final risk score included age, sex, BMI, known hypertension, physical activity at leisure time, and family history of diabetes, items independently and significantly (P < 0.05) associated with the presence of previously undiagnosed diabetes. The area under the receiver operating curve was 0.804 (95% CI 0.765-0.838) for the first half of the Inter99 population, 0.761 (0.720-0.803) for the second half of the Inter99 population, and 0.803 (0.721-0.876) for the ADDITION pilot study. The sensitivity, specificity, and percentage that needed subsequent testing were 76, 72, and 29%, respectively. The false-negative individuals in the risk score had a lower absolute risk of ischemic heart disease compared with the true-positive individuals (11.3 vs. 20.4%; P < 0.0001). We developed a questionnaire to be used in a stepwise screening strategy for type 2 diabetes, decreasing the numbers of subsequent tests and thereby possibly minimizing the economical and personal costs of the screening strategy.


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