Trying to Lose Weight, Losing Weight, and 9-Year Mortality in Overweight U.S. Adults With Diabetes

Gregg, Edward W.; Gerzoff, Robert B.; Thompson, Theodore J.; Williamson, David F.
March 2004
Diabetes Care;Mar2004, Vol. 27 Issue 3, p657
Academic Journal
The aim of this study was to examine the relationships between intention to lose weight, actual weight loss, and all-cause mortality among overweight individuals with diabetes. Individuals trying to lose weight had a 23% lower mortality rate (hazard rate ratio [HRR] 0.77, 95% C1 0.61–0.99) than those who reported not trying to lose weight. This association was as strong for those who failed to lose weight (0.72, 0.55–0.96) as for those who succeeded in losing weight (0.83, 0.63–1.08). Trying to lose weight was beneficial for overweight (BMI 25–30 kg/m2) individuals (0.62, 0.46–0.83) but not for obese (BMI > 30) individuals (1.17, 0.72–1.92). Overall weight loss, without regard to intent, was associated with an increase of 22% (1.22, 0.99–1.50) in the mortality rate. This increase was largely explained by unintentional weight loss, which was associated with a 58% (1.58, 1.08–2.31) higher mortality rate. Overweight diabetic adults trying to lose weight have a reduced risk of all-cause mortality, independent of whether they lose weight. Actual weight loss is associated with increased mortality only if the weight loss is unintentional.


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