TITLE

Expression of the Chemokine Receptors CXCR4 and CCR7 and Disease Progression in B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

AUTHOR(S)
Ghobrial, Irene M.; Bone, Nancy D.; Stenson, Mary J.; Novak, Anne; Hedin, Karen E.; Kay, Neil E.; Ansell, Stephen M.
PUB. DATE
March 2004
SOURCE
Mayo Clinic Proceedings;Mar2004, Vol. 79 Issue 3, p318
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
• Objective: To assess the clinical relevance of chemokine receptor expression on the progression of B-cell chronic lymphocytic leukemia (B-CLL)., • Patients and Methods: Peripheral blood mononuclear cells from 45 patients with B-CLL were purified and compared with lymph node samples collected from 17 of these patients. Also compared were B cells obtained from peripheral blood samples from 5 healthy controls and B cells from reactive lymph nodes from 3 otherwise healthy persons. The patients were treated at the Mayo Clinic in Rochester, Minn, between January 15,1991, and February 7,2003. Mononuclear cells were stained by a 2-color (fluorescein isothiocyanate/phycoerythrin) flow cytometric assay using antibodies to the chemokine receptors (CXCR1, CXCR2, CXCR3, CXCR4, CXCR5 , CCR2, CCR4, CCRS, CCR6, and CCR7) and also to CD19. • Results: Of the 45 patients in this study, 20 had Rai stage 0 disease, 12 had stage I disease, 3 had stage H disease, 2 had stage HI disease, and Shad stage IV disease. The mean fluorescent intensity (MFI) of the chemokine receptor expression on B-CLL cells was compared with normal controls and was not significantly different, except for an increase in the median expression of CXCR3 (P=.003) and CCR7 (P=.001) on B-CLL cells. We also found a significant increase in the expression of CXCR4 and CCR7 in B-CLL cells from patients with stage Pt compared with stage 0 disease (P=.001 and P=.02, respectively). Furthermore, circulating B-CLL cells showed significantly higher expression of CXCR4 and CCR7 when compared with B lymphocytes in lymph nodes (P=.003 and P<001, respectively). • Conclusion: The expression of CXCR4 and CCR7 on B-CLL cells correlates with Rai stage. Also, these chemokine receptors may be down-regulated once malignant B cells enter the lymph nodes. To our knowledge, this is the first published report that shows the strong association of Rai stage with CXCR4 and CCR7 expression levels in B-CLL cells.
ACCESSION #
12389671

 

Related Articles

  • The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact. Schröttner, Percy; Leick, Marion; Burger, Meike // Annals of Hematology;May2010, Vol. 89 Issue 5, p437 

    Chemokines are centrally involved in leukocyte migration, homing and haematopoiesis. Besides these physiological aspects, their role in pathological processes especially with respect to solid tumour and haematological neoplasias is well established. In this context, the focus was set here on...

  • A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment. Ferretti, E.; Bertolotto, M.; Deaglio, S.; Tripodo, C.; Ribatti, D.; Audrito, V.; Blengio, F.; Matis, S.; Zupo, S.; Rossi, D.; Ottonello, L.; Gaidano, G.; Malavasi, F.; Pistoia, V.; Corcione, A. // Leukemia (08876924);Aug2011, Vol. 25 Issue 8, p1268 

    Several chemokines/chemokine receptors such as CCR7, CXCR4 and CXCR5 attract chronic lymphocytic leukemia (CLL) cells to specific microenvironments. Here we have investigated whether the CX3CR1/CX3CL1 axis is involved in the interaction of CLL with their microenvironment. CLL cells from 52...

  • Insights into the multistep transformation process of lymphomas: IgH-associated translocations and tumor suppressor gene mutations in clonally related composite Hodgkin's and non-Hodgkin's lymphomas. Schmitz, R.; Renné, C.; Rosenquist, R.; Tinguely, M.; Distler, V.; Menestrina, F.; Lestani, M.; Stankovic, T.; Austen, B.; Bräuninger, A.; Hansmann, M.-L.; Küppers, R. // Leukemia (08876924);Aug2005, Vol. 19 Issue 8, p1452 

    Clonally related composite lymphomas of Hodgkin's lymphoma (HL) and Non-Hodgkin's lymphoma (NHL) represent models to study the multistep transformation process in tumorigenesis and the development of two distinct tumors from a shared precursor. We analyzed six such lymphomas for transforming...

  • The complement system in chronic B cell lymphoproliferative disorders. Lugassy, G; Schlesinger, M // Leukemia (08876924);Apr98, Vol. 12 Issue 4, p636 

    Focuses on the complement system in chronic lymphocyte leukemia (CLL), a B cell lymphoproliferative disorder. Correlation between hypocomplementemia lymphocyte activation and differentiation stages; Evidence supporting a hereditary background for hypocomplementemia in CLL; Role of complement...

  • Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients. Weissmann, S; Roller, A; Jeromin, S; Hernández, M; Abáigar, M; Hernández-Rivas, J M; Grossmann, V; Haferlach, C; Kern, W; Haferlach, T; Schnittger, S; Kohlmann, A // Leukemia (08876924);Dec2013, Vol. 27 Issue 12, p2393 

    A letter to the editor is presented that discusses NOTCH1 mutations in chronic lymphocytic leukemia.

  • Rosai-Dorfman disease.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p2051 

    A definition of the term "Rosai-Dorfman disease" which refers to a nonmalignant, lymphoproliferative disorder characterized by painless lymph node enlargement, fever and polyclonal hyperglobulinemia is presented.

  • Incidental Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia in Pelvic Lymph Nodes Excised at Radical Prostatectomy. Weir, Edward G.; Epstein, Jonathan I. // Archives of Pathology & Laboratory Medicine;May2003, Vol. 127 Issue 5, p567 

    Context.--Incidental non-Hodgkin lymphoma is often unrecognized at the time of radical prostatectomy in patients with prostate cancer because of nonspecific symptoms and an inconspicuous pathology. The early identification of lymphoma allows optimal long-term management and prevention of...

  • Impact of B-cell count and imaging screening in cMBL: any need to revise the current guidelines? Scarfò, L; Zibellini, S; Tedeschi, A; Maura, F; Neri, A; Bertazzoni, P; Sarina, B; Nalli, G; Motta, M; Rossini, F; Cortelezzi, A; Montillo, M; Orlandi, E; Ghia, P // Leukemia (08876924);Jul2012, Vol. 26 Issue 7, p1703 

    The article examines whether B-cell count and imaging screening can affect clinical monoclonal B-cell lymphocytosis (cMBL). It analyzes a cohort of 684 patients who were diagnosed with Rai stage 0 chronic lymphosytic leukemia (CLL) or cMBL. It supports the recommendation of the guidelines which...

  • Recent advances in the diagnosis and therapy of richter’s syndrome. Ronan Swords; John Bruzzi; Francis Giles // Medical Oncology;Jan2007, Vol. 24 Issue 1, p17 

    Abstract  Richter’s syndrome (RS) denotes the development of aggressive lymphoma that arises in patients with chronic lymphocytic leukemia (CLL). Presenting features typically include a rapid clinical deterioration with fever in the absence of infection, progressive lymph node...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics