Severe Anemia Secondary to a Probable Drug Interaction between Zidovudine and Valproic Acid

Antonio, Tony; Gough, Kevin; Yoong, Deborah; Arbess, Gordon
March 2004
Clinical Infectious Diseases;3/1/2004, Vol. 38 Issue 5, pe38
Academic Journal
A 42-year-old man with human immunodeficiency virus (HIV) infection and a history of complex partial seizures developed severe anemia after the addition of valproic acid to his stable antiretroviral regimen of zidovudine, lamivudine, and abacavir. The inhibition of zidovudine glucuronidation by valproic acid and the resultant zidovudine hematologic toxicity is the proposed mechanism of the interaction.


Related Articles

  • No Cure Yet for HIV-1, But Therapeutic Research Presses On. Schooley, Robert T.; Mellors, John W. // Journal of Infectious Diseases;3/15/2007, Vol. 195 Issue 6, p770 

    The article focuses on the author's comment regarding the study conducted by Siliciano et al. that used sensitive culture methods to further evaluate whether the use of valproic acid might activate HIV-1 from infected CD4 memory T-cells, which reduces the size of the latent viral reservoir in...

  • Valproic acid.  // Reactions Weekly;3/3/2012, Issue 1391, p40 

    The article describes the case of a 30-year-old woman who developed acrocyanosis and nail disorders while under valproic acid treatment regimen for recurrent convulsions.

  • June HIV conference call to focus on prevention of perinatal transmission.  // Public Health Reports;Mar/Apr95, Vol. 110 Issue 2, p232 

    Focuses on the 11th HIV Clinical Conference Call which is scheduled for June 8, 1995. The number of people worldwide who are expected to listen in on the call; Dissemination of information about the clinical implications of administering zidovudine to pregnant women infected with HIV.

  • Disease Progression and Early Viral Dynamics in Human Immunodefiency... Kuhn, Louise; Abrams, Elaine J.; Weedon, Jeremy; Lambert, Genevieve; Schoenbaum, Ellie E.; Nesheim, Steve R.; Palumbo, Paul; Vink, Peter E.; Bultreys, Marc // Journal of Infectious Diseases;7/1/2000, Vol. 182 Issue 1, p104 

    Compares the clinical progression among HIV-infected children born from 1986 to 1997 and exposed or unexposed to zidovudine during prenatal and perinatal periods. Relation between severity of maternal disease and child clinical outcomes; Viral dynamics in first three months of life;...

  • Efavirenz versus Boosted Atazanavir or Zidovudine and Abacavir in Antiretroviral Treatment—Naive, HIV-Infected Subjects: Week 48 Data from the Altair Study. Puls, Rebekah L.; Srasuebkul, Preeyaporn; Petoumenos, Kathy; Boesecke, Christoph; Duncombe, Chris; Belloso, Waldo H.; Molina, Jean-Michel; Lin Li; Avihingsanon, Anchalee; Gazzard, Brian; Cooper, David A.; Emery, Sean // Clinical Infectious Diseases;10/1/2010, Vol. 51 Issue 7, p855 

    Background. Antiretroviral therapy is complicated by drug interactions and contraindications. Novel regimens are needed. Methods. This open label study randomly assigned treatment-naive, human immunodeficiency virus (HIV)- infected subjects to receive tenofovir-emtricitabine with efavirenz (Arm...

  • Lamivudine/zidovudine/abacavir interaction.  // Reactions Weekly;3/4/2006, Issue 1091, p16 

    Discusses research being done on a drug interaction involving lamivudine/zidovudine/abacavir. Reference to a study by C. Fontaine, J.-B. Guiard-Schmid, L. Slama, A. Essid. T Lukiana et al, published in the November 2005 issue of "AIDS"; Complications experienced by a man receiving ciprofibrate...

  • Various drugs.  // Reactions Weekly;2/4/2012, Issue 1387, p32 

    The article describes the cases of 11 patients who developed acute pancreatitis following treatment with codeine in five cases, azathioprine in two cases, and chlorothiazide, valproic acid, rosuvastatin and estradiol in one case each.

  • Valproic acid.  // Reactions Weekly;2/11/2012, Issue 1388, p30 

    The article describes the case of a 2.5-year-old girl who developed paroxysmal tonic upward gaze deviation after shifting to valproic acid for focal temporal lobe epilepsy.

  • Valproic acid/zonisamide.  // Reactions Weekly;8/31/2013, Issue 1467, p37 

    The article presents a case study of a 30-year-old man who received zonisamide and valproic acid, which led to the development of ureteral lithiasis.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics