The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats

Bareyre, Florence M.; Kerschensteiner, Martin; Raineteau, Olivier; Mettenleiter, Thomas C.; Weinmann, Oliver; Schwab, Martin E.
March 2004
Nature Neuroscience;Mar2004, Vol. 7 Issue 3, p269
Academic Journal
In contrast to peripheral nerves, central axons do not regenerate. Partial injuries to the spinal cord, however, are followed by functional recovery. We investigated the anatomical basis of this recovery and found that after incomplete spinal cord injury in rats, transected hindlimb corticospinal tract (CST) axons sprouted into the cervical gray matter to contact short and long propriospinal neurons (PSNs). Over 12 weeks, contacts with long PSNs that bridged the lesion were maintained, whereas contacts with short PSNs that did not bridge the lesion were lost. In turn, long PSNs arborize on lumbar motor neurons, creating a new intraspinal circuit relaying cortical input to its original spinal targets. We confirmed the functionality of this circuit by electrophysiological and behavioral testing before and after CST re-lesion. Retrograde transynaptic tracing confirmed its integrity, and revealed changes of cortical representation. Hence, after incomplete spinal cord injury, spontaneous extensive remodeling occurs, based on axonal sprout formation and removal. Such remodeling may be crucial for rehabilitation in humans.


Related Articles

  • Abundant Expression of Guidance and Synaptogenic Molecules in the Injured Spinal Cord. Jacobi, Anne; Schmalz, Anja; Bareyre, Florence M. // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Background: Spinal interneurons have emerged as crucial targets of supraspinal input during post-injury axonal remodelling. For example, lesioned corticospinal projections use propriospinal neurons as relay stations to form intraspinal detour circuits that circumvent the lesion site and...

  • Near Infrared Raman Spectroscopic Study of Reactive Gliosis and the Glial Scar in Injured Rat Spinal Cords. Saxena, Tarun; Deng, Bin; Lewis-Clark, Eric; Hoellger, Kyle; Stelzner, Dennis; Hasenwinkel, Julie; Chaiken, Joseph // AIP Conference Proceedings;8/6/2010, Vol. 1267 Issue 1, p400 

    The article offers information on the findings of a research on near infrared Raman spectroscopic study of reactive gliosis and the glial scar in injured rat spinal cords. Comparative Raman spectra of ex vivo, injured and healthy rat spinal cord were taken. The experiments using enzymatic...

  • EphA4 Blockers Promote Axonal Regeneration and Functional Recovery Following Spinal Cord Injury in Mice. Goldshmit, Yona; Spanevello, Mark D.; Tajouri, Sophie; Li, Li; Rogers, Fiona; Pearse, Martin; Galea, Mary; Bartlett, Perry F.; Boyd, Andrew W.; Turnley, Ann M. // PLoS ONE;2011, Vol. 6 Issue 9, p1 

    Upregulation and activation of developmental axon guidance molecules, such as semaphorins and members of the Eph receptor tyrosine kinase family and their ligands, the ephrins, play a role in the inhibition of axonal regeneration following injury to the central nervous system. Previously we have...

  • Retinoic acid in the development, regeneration and maintenance of the nervous system. Maden, Malcolm // Nature Reviews Neuroscience;Oct2007, Vol. 8 Issue 10, p755 

    Retinoic acid (RA) is involved in the induction of neural differentiation, motor axon outgrowth and neural patterning. Like other developmental molecules, RA continues to play a role after development has been completed. Elevated RA signalling in the adult triggers axon outgrowth and,...

  • A Schwann cell mitogen accompanying regeneration of motor neurons. Livesey, Frederick J.; O'Brien, John A. // Nature;12/11/1997, Vol. 390 Issue 6660, p614 

    Presents research which identified an extracellular signaling molecule that is expressed solely in regenerating and developing rat motor and sensory neurons. Regeneration of motor neurons following injury; Use of technique called messenger RNA differential display; Axon-stimulated Schwann cell...

  • Schwann cells and endoneurial extracellular matrix molecules as potential cues for sorting of regenerated axons: A review. Dubovy, Petr // Anatomical Science International;Dec2004, Vol. 79 Issue 4, p198 

    Besides very well elaborated microsurgical management of severed peripheral nerves, the clinical results of functional recovery following surgical repair of mixed nerves are disappointing. An improvement of functional recovery after peripheral nerve lesion requires the accurate regeneration of...

  • The Impact of Motor Axon Misdirection and Attrition on Behavioral Deficit Following Experimental Nerve Injuries. Alant, Jacob Daniel de Villiers; Senjaya, Ferry; Ivanovic, Aleksandra; Forden, Joanne; Shakhbazau, Antos; Midha, Rajiv // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Peripheral nerve transection and neuroma-in-continuity injuries are associated with permanent functional deficits, often despite successful end-organ reinnervation. Axonal misdirection with non-specific reinnervation, frustrated regeneration and axonal attrition are believed to be among the...

  • A Long-Term Pilot Study on Sex and Spinal Cord Injury Shows Sexual Dimorphism in Functional Recovery and Cardio-Metabolic Responses. Ghnenis, Adel B.; Burns, Daniel T.; Osimanjiang, Wupu; He, Guanglong; Bushman, Jared S. // Scientific Reports;2/17/2020, Vol. 10 Issue 1, p1 

    More than a quarter of a million individuals in the US live with spinal cord injury (SCI). SCI disrupts neural circuitry to vital organs in the body. Despite severe incidences of long-term peripheral complications from SCI, the cardio-metabolic consequences and divergences in sex-related...

  • Pathological Changes in the White Matter after Spinal Contusion Injury in the Rat. Ek, C. Joakim; Habgood, Mark D.; Dennis, Ross; Dziegielewska, Katarzyna M.; Mallard, Carina; Wheaton, Benjamin; Saunders, Norman R.; Combs, Colin // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    It has been shown previously that after spinal cord injury, the loss of grey matter is relatively faster than loss of white matter suggesting interventions to save white matter tracts offer better therapeutic possibilities. Loss of white matter in and around the injury site is believed to be...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics