Neuroscience: Immigration denied
Tags: NEURONS; BRAIN; NERVOUS system -- Degeneration; NEURAL stem cells; PARKINSON'S disease; CELLS
Related Articles
- Adult Neurogenesis and the Diseased Brain. Vandenbosch, Renaud; Borgs, Laurence; Beukelaers, Pierre; Belachew, Shibeshih; Moonen, Gustave; Nguyen, Laurent; Malgrange, Brigitte // Current Medicinal Chemistry;Feb2009, Vol. 16 Issue 6, p652
For a long time it was believed that the adult mammalian brain was completely unable to regenerate after insults. However, recent advances in the field of stem cell biology, including the identification of adult neural stem cells (NSCs) and evidence regarding a continuous production of neurons...
- The potential of hematopoietic growth factors for treatment of Alzheimer's disease: a mini-review. Sanchez-Ramos, Juan; Shijie Song; Chuanhai Cao; Arendash, Gary // BMC Neuroscience;2008 Supplement 2, Vol. 9, Special section p1
There are no effective interventions that significantly forestall or reverse neurodegeneration and cognitive decline in Alzheimer's disease. In the past decade, the generation of new neurons has been recognized to continue throughout adult life in the brain's neurogenic zones. A major challenge...
- Endogenous Regulation of Neural Stem Cells in the Adult Mammalian Brain. Coronas, Valerie // Central Nervous System Agents in Medicinal Chemistry;Jun2009, Vol. 9 Issue 2, p110
Tissue-specific stem cells replenish organs by replacing cells lost due to tears and wears or injury throughout life. Long considered as an exception to this rule, the adult mammalian brain has consistently been found to possess stem cells that ensure neurogenesis. Neural stem cells persist...
- Biphasic Electrical Currents Stimulation Promotes both Proliferation and Differentiation of Fetal Neural Stem Cells. Keun-A Chang; Jin Won Kim; Jeong a Kim; Sungeun Lee; Saeromi Kim; Won Hyuk Suh; Hye-Sun Kim; Sunghoon Kwon; Sung June Kim; Yoo-Hun Suh // PLoS ONE;2011, Vol. 6 Issue 4, p1
The use of non-chemical methods to differentiate stem cells has attracted researchers from multiple disciplines, including the engineering and the biomedical fields. No doubt, growth factor based methods are still the most dominant of achieving some level of proliferation and differentiation...
- Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression. Lewerenz, J; Sato, H; Albrecht, P; Henke, N; Noack, R; Methner, A; Maher, P // Cell Death & Differentiation;May2012, Vol. 19 Issue 5, p847
Selecting neuronal cell lines for resistance against oxidative stress might recapitulate some adaptive processes in neurodegenerative diseases where oxidative stress is involved like Parkinson's disease. We recently reported that in hippocampal HT22 cells selected for resistance against...
- Dopaminergic Neurons from Midbrain-Specified Human Embryonic Stem Cell-Derived Neural Stem Cells Engrafted in a Monkey Model of Parkinson's Disease. Daadi, Marcel M.; Grueter, Brad A.; Malenka, Robert C.; Redmond, Jr., D. Eugene; Steinberg, Gary K. // PLoS ONE;Jul2012, Vol. 7 Issue 7, p1
The use of human embryonic stem cells (hESCs) to repair diseased or injured brain is promising technology with significant humanitarian, societal and economic impact. Parkinson's disease (PD) is a neurological disorder characterized by the loss of midbrain dopaminergic (DA) neurons. The...
- Regulation of Neural Stem Cells in the Human SVZ by Trophic and Morphogenic Factors. �lvarez-Palazuelos, Lucia E.; Robles-Cervantes, Martha S.; Castillo-Vel�zquez, Gabriel; Rivas-Souza, Mario; Guzman-Muniz, Jorge; Moy-Lopez, Norma; Gonz�lez-Casta�eda, Roc�o E.; Luqu�n, Sonia; Gonzalez-Perez, Oscar // Current Signal Transduction Therapy;Sep2011, Vol. 6 Issue 3, p320
The subventricular zone (SVZ), lining the lateral ventricular system, is the largest germinal region in mammals. In there, neural stem cells express markers related to astroglial lineage that give rise to new neurons and oligodendrocytes in vivo. In the adult human brain, in vitro evidence has...
- Glial Cell Lineage Expression of Mutant Ataxin-1 and Huntingtin Induces Developmental and Late-Onset Neuronal Pathologies in Drosophila Models. Tamura, Takuya; Sone, Masaki; Yamashita, Mayumi; Wanker, Erich E.; Okazawa, Hitoshi // PLoS ONE;2009, Vol. 4 Issue 1, p1
Background: In several neurodegenerative disorders, toxic effects of glial cells on neurons are implicated. However the generality of the non-cell autonomous pathologies derived from glial cells has not been established, and the specificity among different neurodegenerative disorders remains...
- Mild Hypoxia Enhances Proliferation and Multipotency of Human Neural Stem Cells. Santilli, Guido; Lamorte, Giuseppe; Carlessi, Luigi; Ferrari, Daniela; Nodari, Laura Rota; Binda, Elena; Delia, Domenico; Vescovi, Angelo L.; De Filippis, Lidia // PLoS ONE;2010, Vol. 5 Issue 1, p1
Background: Neural stem cells (NSCs) represent an optimal tool for studies and therapy of neurodegenerative diseases. We recently established a v-myc immortalized human NSC (IhNSC) line, which retains stem properties comparable to parental cells. Oxygen concentration is one of the most crucial...
