TITLE

Predictive Value of Assessment of Lymph Node Weight and T-Lymphocyte Proliferation in Contact Sensitivity in Acrylates

AUTHOR(S)
Bull, J.E.; Parker, Darien; Turk, J. L.
PUB. DATE
November 1985
SOURCE
Journal of Investigative Dermatology;Nov85, Vol. 85 Issue 5, p403
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An assessment of T-lymphocyte proliferation and lymph node weight is proposed as a predictive test for contact sensitizers of industrial origin. Data are presented showing increased T-lymphocyte proliferation following epicutaneous application of a variety of industrially important acrylate-like chemicals which appear to correlate well with their ability to sensitize in the guinea pig. These data were compared with those obtained after application of 2,4-dinitro-l-fluorobenzene (DNFB) a strong sensitizer, and 2,4-dinitrothiocyanatebenzene (DNTB) a nonsensitizer when given epicutaneously. It is suggested that this quantitative approach, in parallel with a simple one-dose immunization, may provide a better picture of sensitization potential than the longer multidose immunizations currently in use.
ACCESSION #
12277061

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics