TITLE

Polymorphisms of lipid metabolism enzyme-coding genes in patients with diabetic dyslipidemia

AUTHOR(S)
Vardarlı, Aslı Tetik; Harman, Ece; Çetintaş, Vildan Bozok; Kayıkçıoğlu, Meral; Vardarlı, Egemen; Zengi, Ayhan; Küçükaslan, Ali Şahin; Eroğlu, Zuhal
PUB. DATE
April 2017
SOURCE
Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi;Apr2017, Vol. 17 Issue 4, p313
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: The polymorphisms/mutations of genes encoding proteins and enzymes involved in lipoprotein metabolism play important roles in the development of diabetic dyslipidemia. The aim of our study was to investigate the effects of LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), PON1 (rs662), and MNSOD (rs4880) gene polymorphisms on lipid metabolism and diabetic dyslipidemia. Methods: This case-control study included 217 patients with diabetic dyslipidemia and 212 healthy age- and gender-matched individuals. Genomic DNA isolation was performed from blood samples, and genotype analysis was performed using melting curve analysis on a LightCycler® 480 Instrument. The chi-square test was used to compare genotype distribution and allele frequencies between the groups. Results: Significant associations were observed between LPL (rs320) (p<0.001), LIPC (rs2070895) (p<0.001), SCARB1 (rs5888) (p<0.001), LCAT (rs2292318) (p<0.001), CETP (rs708272) (p<0.001), ADIPOQ (rs1501299) (p=0.01), RETN (rs3745367) (p<0.001), and MNSOD (rs4880) (p<0.001) polymorphisms and diabetic dyslipidemia. However, no association was observed between PON1 (rs662) polymorphisms and diabetic dyslipidemia (p=0.611). Conclusion: LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), and MNSOD (rs4880) polymorphisms play an important role in basic molecular metabolism in diabetic dyslipidemia. Therefore, these polymorphisms may be used as a predictive marker for diabetic dyslipidemia in high-risk patients.
ACCESSION #
122473823

 

Related Articles

  • Adaptive dynamics of saturated polymorphisms. Kisdi, Éva; Geritz, Stefan // Journal of Mathematical Biology;Mar2016, Vol. 72 Issue 4, p1039 

    We study the joint adaptive dynamics of n scalar-valued strategies in ecosystems where n is the maximum number of coexisting strategies permitted by the (generalized) competitive exclusion principle. The adaptive dynamics of such saturated systems exhibits special characteristics, which we first...

  • Polymorphism of the Porcine Leptin Gene Promoter and Analysis of Its Association with Gene Expression and Fatness Traits. M. Stachowiak; M. Mackowski; Z. Madeja; M. Szydlowski; A. Buszka; P. Kaczmarek; B. Rubis; P. Mackowiak; K. W. Nowak; M. Switonski // Biochemical Genetics;Apr2007, Vol. 45 Issue 3/4, p245 

    We describe for the first time a 245 bp fragment of the porcine leptin gene promoter in the proximity of the transcription start site. Altogether, 720 pigs were screened with the PCR-SSCP technique for polymorphism in this region. Four SNPs, segregating as two haplotypes, have been identified,...

  • Genetic Typing of Corallium rubrum. del Gaudio, D.; Fortunato, G.; Borriello, M.; Gili, J. M.; Buono, P.; Calcagno, G.; Salvatore, F.; Sacchetti, L. // Marine Biotechnology;Nov/Dec2004, Vol. 6 Issue 6, p511 

    Corallium rubrum taxonomy is based on morphologic criteria; little is known about its genome. We set up a rapid, easy method based on amplified fragment length polymorphism to characterize the genetic patterns of C. rubrum in an attempt to understand better the evolutionary relations between...

  • Color polymorphism and intrasexual competition in assemblages of cichlid fish. Peter D. Dijkstra; Charlotte Hemelrijk; Ole Seehausen; Ton G.G. Groothuis // Behavioral Ecology;Jan2009, Vol. 20 Issue 1, p138 

    The origin and maintenance of phenotypic polymorphisms is a classical problem in evolutionary ecology. Aggressive male–male competition can be a source of negative frequency-dependent selection stabilizing phenotypic polymorphisms when aggression is biased toward the own morph. We studied...

  • Cytochrome- b variation in Apis mellifera samples and its association with COI–COII patterns. Kátia Ferreira; Otávio e Silva; Maria Arias; Marco Del Lama // Genetica;Mar2009, Vol. 135 Issue 2, p149 

    Abstract  Five Mbo I (Mbo-A, Mbo-M, Mbo-C1, Mbo-C2 and Mbo-C3) and Hinf I (Hinf-1 to Hinf-5) patterns were observed in Apis mellifera samples after restriction of a 485 bp fragment of the mitochondrial cytochrome-b (cyt-b) gene. Associating the cyt-b Restriction fragment length...

  • Taxonomic study on two Chinese species of the genus Cerynia (Hemiptera, Fulgoromorpha, Flatidae). Weicheng Yang; Xiangsheng Chen // ZooKeys;2014, Issue 431, p51 

    Male genitalia of the species Cerynia lineola Melichar is described and illustrated for the first time from China. Colour polymorphism in a planthopper species Cerynia maria (White, 1846) is investigated based on some specimens from China, and a map showing the geographic distribution of this...

  • Influence of Latitude and Elevation on Polymorphism Among Populations of the Corn Leafhopper, Dalbulus maidis (DeLong and Wolcott) (Hemiptera: Cicadellidae), in Brazil. de Oliveira, Charles Martins; Lopes, João Roberto Spotti; Dias, Carlos Tadeu Dos Santos; Nault, Lowell R. // Environmental Entomology;Oct2004, Vol. 33 Issue 5, p1192 

    Morphological variations in insects have been shown to be influenced by latitude and elevation. Here we show that these two parameters markedly influence the appearance of the corn leafhopper Dalbulus maidis (DeLong and Wolcott). Leafhopper samples were collected in maize from 27 localities in...

  • Dispersal Polymorphism and the Speed of Biological Invasions. Elliott, Elizabeth C.; Cornell, Stephen J. // PLoS ONE;Jul2012, Vol. 7 Issue 7, p1 

    The speed at which biological range expansions occur has important consequences for the conservation management of species experiencing climate change and for invasion by exotic organisms. Rates of dispersal and population growth are known to affect the speed of invasion, but little is known...

  • Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving. Cagliani, Rachele; Riva, Stefania; Pozzoli, Uberto; Fumagalli, Matteo; Comi, Giacomo P.; Bresolin, Nereo; Clerici, Mario; Sironi, Manuela // BMC Evolutionary Biology;2011, Vol. 11 Issue 1, p171 

    Background: Several susceptibility genetic variants for autoimmune diseases have been identified. A subset of these polymorphisms displays an opposite risk profile in different autoimmune conditions. This observation open interesting questions on the evolutionary forces shaping the frequency of...

  • Polymorphism of the pig pre-implantation protein 3 (prei3) gene and its association with litter size traits. Niu, B. Y.; Xiong, Y. Z.; Li, F. E.; Deng, C. Y.; Jiang, S. W.; Ye, L. Z.; Wang, J.; Ding, S. H.; Guo, W. H. // South African Journal of Animal Science;2006, Vol. 36 Issue 3, p209 

    The pre-implantation protein 3 (prei3), which might play a role in pre-implantation embryogenesis, is one of the promising candidate genes for litter size traits in pigs. In this study, a single nucleotide polymorphism (SNP: T802G) in intron 6 of the pig prei3 gene was detected and a genotyping...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics