Unusual Presentation of Life-Threatening Toscana Virus Meningoencephalitis

Baldelli, Franco; Ciufolini, Maria Grazia; Francisci, Daniela; Marchi, Antonella; Venturi, Giulietta; Fiorentini, Cristiano; Luchetta, Maria Laura; Bruto, Lidia; Pauluzzi, Sergio
February 2004
Clinical Infectious Diseases;2/15/2004, Vol. 38 Issue 4, p515
Academic Journal
This case report describes a brother and a sister with severe meningoencephalitis caused by Toscana virus (TOSv). The clinical presentation was characterized by stiff neck, deep coma, maculopapular rash, diffuse lymphadenopathy, hepatosplenomegaly, renal involvement, tendency to bleeding, and diffuse intravascular coagulation. The boy had epididymo-orchitis. Recovery with neurologic sequelae as hydrocephalus was observed. Microbiological diagnosis was obtained by serological tests and reverse transcriptase-polymerase chain reaction. Sequencing of polymerase chain reaction products from the S and M segments was carried out. TOSv may be a causative agent in severe meningoencephalitis.


Related Articles

  • More Challenges From Ebola: Infection of the Central Nervous System. Gary Wong; Xiangguo Qiu; Yuhai Bi; Formenty, Pierre; Sprecher, Armand; Jacobs, Michael; Gao, George F.; Kobinger, Gary // Journal of Infectious Diseases;2016 Supplement, Vol. 214, pS294 

    Cases of relapsed Ebola virus disease involving symptoms in the central nervous system are reminiscent of our past observations with some nonhuman primates (NHPs) that survived acute Ebola virus infection. We document our findings in detail here and suggest that this phenomenon can be further...

  • Three ECHOvirus Serotypes Responsible for Outbreak of Aseptic Meningitis in Rhône-Alpes Region, France. Chomel, J.-J.; Antona, D.; Thouvenot, D.; Lina, B. // European Journal of Clinical Microbiology & Infectious Diseases;Mar2003, Vol. 22 Issue 3, p191 

    During the year 2000 in the Rhône-Alpes region of France, 559 cases of aseptic meningitis due to enterovirus infection were recorded (approximate incidence, 10 cases per 100,000 population compared with a mean of 0.3 cases during endemic years in this region; P<0.001). Cerebrospinal fluid...

  • Transcriptional targeting of sphingosine-1-phosphate receptor S1P2 by epigallocatechin-3-gallate prevents sphingosine-1-phosphate-mediated signaling in macrophage-differentiated HL-60 promyelomonocytic leukemia cells. Chokor, Rima; Lamy, Sylvie; Annabi, Borhane // OncoTargets & Therapy;2014, Vol. 7, p667 

    Background: Macrophage chemotaxis followed by blood-brain barrier transendothelial migration is believed to be associated with inflammation in the central nervous system. Antineuroinflammatory strategies have identified the dietary-derived epigallocatechin-3-gallate (EGCG) as an efficient agent...

  • Selection of housekeeping genes for normalization of RT-PCR in hypoxic neural stem cells of rat in vitro. Yao, Lu; Chen, Xinlin; Tian, Yingfang; Lu, Haixia; Zhang, Pengbo; Shi, Qindong; Zhang, Junfeng; Liu, Yong // Molecular Biology Reports;Jan2012, Vol. 39 Issue 1, p569 

    Gene expression analysis under various conditions using real-time reverse transcription polymerase chain reaction (RT-PCR) needs reliable control genes. Housekeeping genes are commonly used as the control. However, no validated housekeeping gene is available for study of hypoxic neural stem cell...

  • Chlamydia pneumoniae infection of monocytes in vitro stimulates innate and adaptive immune responses relevant to those in Alzheimer's disease. Charles Lim; Hammond, Christine J.; Hingley, Susan T.; Balin, Brian J. // Journal of Neuroinflammation;2014, Vol. 11 Issue 1, p375 

    Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which infection with Chlamydia pneumoniae (Cpn) has been associated. Cpn is an obligate intracellular respiratory pathogen that may enter the central nervous system (CNS) following infection and trafficking of...

  • DIFFERENTIAL DIAGNOSIS OF RESPIRATORY VIRUSES BY USING REALTIME RT-PCR METHODOLOGY. de Souza PAULINO, Renato; BENEGA, Margarete Aparecida; de Oliveira SANTOS, Katia Correa; da SILVA, Daniela Bernardes Borges; PEREIRA, Juliana Cristina; SASAKI, Norio Augusto; SILVA, Patricia Evelin; CURTI, Suely Pires; OLIVEIRA, Maria Isabel; CARVALHANAS, Telma R. M. P.; PERET, Teresa; ERDMAN, Dean; de PAIVA, Terezinha Maria // Revista do Instituto de Medicina Tropical de Sao Paulo;Nov/Dec2013, Vol. 55 Issue 6, p432 

    A letter to the editor is presented related to the diagnosis of new respiratory viruses such as coronavirus and influenza A (H1N1) pdmO9 by using Real Time Reverse Transcriptase-Polymerase Chain Reaction (PCR) Methodology.

  • Surveillance of Human Astrovirus Infection in Brazil: The First Report of MLB1 Astrovirus. Xavier, Maria da Penha Trindade Pinheiro; Carvalho Costa, Filipe Aníbal; Rocha, Mônica Simões; Andrade, Juliana da Silva Ribeiro de; Diniz, Fernanda Kreischer Bandeira; Andrade, Thais Ramos de; Miagostovich, Marize Pereira; Leite, José Paulo Gagliardi; Volotão, Eduardo de Mello // PLoS ONE;8/14/2015, Vol. 10 Issue 8, p1 

    Human astrovirus (HAstV) represents the third most common virus associated with acute diarrhea (AD). This study aimed to estimate the prevalence of HAstV infection in Brazilian children under 5 years of age with AD, investigate the presence of recently described HAstV strains, through extensive...

  • Sapovirus in Adults in Rehabilitation Center, Upper Austria. Mikula, Claudia; Springer, Burkhard; Reichart, Sandra; Bierbacher, Katharina; Lichtenschopf, Alfred; Hoehne, Marina // Emerging Infectious Diseases;Jul2010, Vol. 16 Issue 7, p1186 

    The article focuses on a study of an outbreak of gastroenteritis in a rehabilitation center in Upper Austria. Twenty-one adults and 12 staff members showed such signs as diarrhea, vomiting and fever. Reverse transcription-polymerase chain reaction (PCR) testing showed the presence of sapovirus...

  • Burden of Human Metapneumovirus Infection in Young Children. John Jr., Joseph F. // Infectious Disease Alert;Mar2013, Vol. 32 Issue 6, p66 

    Human metapneumovirus (HMPV) was only discovered about a decade ago and until this study the extent of the disease -- particularly in the young -- was not known. Over a six year period, three sites (Cincinnati, Nashville, Rochester, NY) studied the prevalence in children less than 5 years old....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics