TITLE

Unusual Presentation of Life-Threatening Toscana Virus Meningoencephalitis

AUTHOR(S)
Baldelli, Franco; Ciufolini, Maria Grazia; Francisci, Daniela; Marchi, Antonella; Venturi, Giulietta; Fiorentini, Cristiano; Luchetta, Maria Laura; Bruto, Lidia; Pauluzzi, Sergio
PUB. DATE
February 2004
SOURCE
Clinical Infectious Diseases;2/15/2004, Vol. 38 Issue 4, p515
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This case report describes a brother and a sister with severe meningoencephalitis caused by Toscana virus (TOSv). The clinical presentation was characterized by stiff neck, deep coma, maculopapular rash, diffuse lymphadenopathy, hepatosplenomegaly, renal involvement, tendency to bleeding, and diffuse intravascular coagulation. The boy had epididymo-orchitis. Recovery with neurologic sequelae as hydrocephalus was observed. Microbiological diagnosis was obtained by serological tests and reverse transcriptase-polymerase chain reaction. Sequencing of polymerase chain reaction products from the S and M segments was carried out. TOSv may be a causative agent in severe meningoencephalitis.
ACCESSION #
12174941

 

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