Predicting Relapse after Cessation of Lamivudine Monotherapy for Chronic Hepatitis B Virus Infection

Ito, Kiyoaki; Tanaka, Yasuhito; Onto, Etsuro; Hirashima, Noboru; Ide, Tatsuya; Hino, Teruko; Kumashiro, Ryukichi; Kato, Atunaga; Nukaya, Haruhiko; Sakakibara, Kenji; Mukaide, Motokazu; Ito, Hidemi; Sata, Michio; Ueda, Ryuzo; Mizokami, Masashi
February 2004
Clinical Infectious Diseases;2/15/2004, Vol. 38 Issue 4, p490
Academic Journal
There have been reports of relapse after cessation of lamivudine monotherapy for hepatitis B virus (HBV) infection. The aim of this study was to examine factors that predict posttreatment relapse. Comparison 22 patients who experienced relapse with 11 who did not after cessation of therapy showed that predictive factors for nonrelapse were hepatitis B e antigen seroconversion and duration of undetectable HBV DNA load (<0.7 log IU/mL), as determined by HBV real-time detection direct testing. However, 7 of 12 patients with seroconversion experienced relapse after cessation of therapy. Multivariate analysis revealed that the duration of an undetectable HBV DNA load was the only independent predictive factor for nonrelapse (odds ratio, 0.50; 95% confidence interval, 0.27-0.9). More-prolonged lamivudine therapy is required after seroconversion, and persistent duration of an HBV DNA level of <0.7 log IU/mL for >6 months can more accurately aid in the decision of when to stop lamivudine therapy.


Related Articles

  • The influence of hepatitis B DNA level and antiviral therapy on recurrence after initial curative treatment in patients with hepatocellular carcinoma. Chuma, Makoto; Hige, Shuhei; Kamiyama, Toshiya; Meguro, Takashi; Nagasaka, Atsushi; Nakanishi, Kazuaki; Yamamoto, Yoshiya; Nakanishi, Mitsuru; Kohara, Toshihisa; Sho, Takuya; Yamamoto, Keiko; Horimoto, Hiromasa; Kobayashi, Tomoe; Yokoo, Hideki; Matsushita, Michiaki; Todo, Satoru; Asaka, Masahiro // Journal of Gastroenterology;2009, Vol. 44 Issue 9, p991 

    Prediction and prevention of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) recurrence is an important clinical issue. We investigated whether HBV DNA level and antiviral therapy are associated with HCC recurrence. This retrospective study involved 103 patients who underwent...

  • Hepatitis B virus infection among different sex and age groups in Pakistani Punjab. Khan, Fawad; Shams, Sulaiman; Qureshi, Ihteshamud Din; Israr, Muhmmad; Khan, Hayat; Sarwar, Muhammad Tahir; Ilyas, Muhammad // Virology Journal;2011, Vol. 8 Issue 1, p225 

    Background: Hepatitis B virus (HBV) infection is a serious health problem in the developing countries including Pakistan. Various risk factors are responsible for the spread of this infectious disease. Prevalence of HBV infection in apparently suspected individual of Punjab province of Pakistan...

  • Suppression of HBV by HCV. Wisecarver, J. L.; Thompson, Jon S. // American Journal of Gastroenterology;Nov1999, Vol. 94 Issue 11, p3109 

    Discusses research being done on the reduction of positive staining among patients infected with both hepatitis B and C viruses. Reference to a study by M. Guido and colleagues published in a 1999 issue of "Modern Pathology"; Process of diagnosing hepatitis B viral antigens in liver biopsies;...

  • Factors associated with spontaneous HBsAg clearance in chronic hepatitis B patients followed at a university hospital. Ferreira, Sandro C.; Chachá, Silvana G. F.; Souza, Fernanda F.; Teixeira, Andreza C.; Santana, Rodrigo C.; Villanova, Márcia G.; Zucoloto, Sérgio; Ramalho, Leandra N.; Perdoná, Gleici S. C.; Passos, Afonso D. C.; Martinelli, Ana L. C. // Annals of Hepatology: Official Journal of the Mexican Associatio;Nov/Dec2014, Vol. 13 Issue 6, p762 

    Introduction. Few studies have evaluated the factors involved in the spontaneous HBsAg seroclearance in patients with chronic hepatitis B (HBV) followed up on a long-term basis from areas with a low prevalence of HBV infection. We aimed to determine the rate of spontaneous HBsAg seroclearance...

  • Pseudoknots: RNA Structures with Diverse Functions. Staple, David W.; Butcher, Samuel E. // PLoS Biology;Jun2005, Vol. 3 Issue 6, p0956 

    The article reports that RNA molecules fulfill a diverse set of biological functions within cells, from the transfer of genetic information from DNA to protein, to enzymatic catalysis. Reflecting this range of roles, simple linear strings of RNA--made up of uracil, guanine, cytosine, and...

  • Predicting response to peginterferon α-2a, lamivudine and the two combined for HBeAg-negative chronic hepatitis B. Bonino, F.; Marcellin, P.; Lau, G. K. K.; Hadziyannis, S.; Jin, R.; Piratvisuth, T.; Germanidis, G.; Yurdaydin, C.; Diago, M.; Gurel, S.; Lai, M.-Y.; Brunetto, M. R.; Farci, P.; Popescu, M.; McCloud, P. // Gut;May2007, Vol. 56 Issue 5, p699 

    Objective: In a trial of patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B, 24 week post-treatment biochemical and virological response rates with peginterferon α-2a with or without lamivudine were significantly higher than with lamivudine alone. The effect of...

  • Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma. Chan, H. L.-Y.; Hui, A. Y.; Wong, M. L.; Tse, A. M.-L.; Hung, L. C.-T.; Wong, V. W.-S.; Sung, J. J.-Y. // Gut;Oct2004, Vol. 53 Issue 10, p1494 

    Background: Identification of risk factors for the development of hepatocellular carcinoma (HCC) is important for HCC surveillance in chronic hepatitis B virus (HBV) infection. Our aim was to study the independent risk factors and effect of HBV genotypes on HCC development in a prospective...

  • Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. Najafizadeh, Mohammad; Farhadi, Naser; Sarkari, Bahador // Journal of Applied Biological Sciences;May2009, Vol. 3 Issue 2, p53 

    It is generally believed that viral clearance or chronic infection following hepatitis B virus (HBV) infection is linked to the genetic background of the host and human leukocyte antigens (HLA) play a central role. This study was conducted to determine associations between some of HLA class I...

  • VIRAL HEPATITIS OF MAN AND NONHUMAN PRIMATES.  // Zoonoses & Communicable Diseases Common to Man & Animals;2003, Vol. 1-3, p356 

    The article offers information on viral hepatitis of man and nonhuman primates. It states that hepatitis A, B, C, and D viruses are distributed worldwide. Epidemics have been caused by the HEV virus. When the human disease is associated with nonhuman primates, the infection is usually mild and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics