TITLE

Lysine kinetics in preterm infants: the importance of enteral feeding

AUTHOR(S)
van der Schoor, S R D; Reeds, P J; Stellaard, F; Wattimena, J D L; Sauer, P J J; Büller, H A; van Goudoever, J B
PUB. DATE
January 2004
SOURCE
Gut;Jan2004, Vol. 53 Issue 1, p38
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
INTRODUCTION: Lysine is the first limiting essential amino acid in the diet of newborns. First pass metabolism by the intestine of dietary lysine has a direct effect on systemic availability. We investigated whether first pass lysine metabolism in the intestine is high in preterm infants, particularly at a low enteral intake. PATIENTS AND METHODS: Six preterm infants (birth weight 0.9 (0.1) kg) were studied during two different periods: period A (n = 6): 40% of intake administered enterally, 60% parenterally; lysine intake 92 (6) micromol/(kg x h); and period B (n = 4): 100% enteral feeding; lysine intake 100 (3) micromol/(kg x h). Dual stable isotope tracer techniques were used to assess splanchnic and whole body lysine kinetics. RESULTS: Fractional first pass lysine uptake by the intestine was significantly higher during partial enteral feeding (period A 32 (10)% v period B 18 (7)%; p<0.05). Absolute uptake was not significantly different. Whole body lysine oxidation was significantly decreased during full enteral feeding (period A 44 (9) v period B 17 (3) micromol/(kg x h); p<0.05) so that whole body lysine balance was significantly higher during full enteral feeding (period A 52 (25) v period B 83 (3) micromol/(kg x h); p<0.05). CONCLUSIONS: Fractional first pass lysine uptake was much higher during partial enteral feeding. Preterm infants receiving full enteral feeding have lower whole body lysine oxidation, resulting in a higher net lysine balance, compared with preterm infants receiving partial enteral feeding. Hence parenterally administered lysine is not as effective as dietary lysine in promoting protein deposition in preterm infants.
ACCESSION #
12136738

 

Related Articles

  • Effect of Aggressive Early High-Dose Intravenous Amino Acid Infusion and Early Trophic Enteral Nutrition on Very Low Birth Weight Infants. Man-Yau Ho; Yu-Hsuan Yen; Hsiang-Yin Chen; Shu-Chen Chien; Mao-Chih Hsieh; Yao-Shun Yang // Food & Nutrition Sciences;Nov2012, Vol. 3 Issue 11, p1604 

    Objective: Very-low-birth-weight (VLBW) preterm infants are at risk of growth delay if they do not receive adequate nutritional support. This study evaluated the effect of aggressive early high-dose amino acid infusion plus early enteral trophic feeding on growth in VLBW infants within the first...

  • Choice of booking: postnatal implications for infants requiring neonatal community care. Mahaveer, A. K.; May, J.; Curley, A. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Feb2010, Vol. 95 Issue 2, pF150 

    The article discusses research being done on breastfeeding in preterm infants referencing the study "Early Discharge With Tube Feeding at Home for Preterm Infants is Associated with Longer Duration of Breastfeeding," by Z. E. Meerlo-Habing et al. published in the 2009 issue of "Archives of...

  • Benefits of early enteral nutrition in extremely low birth weight infants. Manea, Aniko; Boia, Marioara; Iacob, Daniela; Dima, Mirabela; Iacob, Radu Emil // Singapore Medical Journal;2016, Vol. 57 Issue 11, p616 

    Introduction: Extremely low birth weight (ELBW) infants (i.e. preterm infants weighing < 1,000 g) often present with morphofunctional multiple organ immaturity. This study aimed to determine whether early enteral feeding improves digestive tolerance, and whether there is a...

  • Current Trends in the Nutrition and Feeding of the Preterm Infant. Llanos, Adolfo; Uauy, Ricardo // International Seminars in Pediatric Gastroenterology & Nutrition;Dec2002, Vol. 11 Issue 4, p1 

    Provides information on the nutritional needs of premature infants. Recommendations on nutrient intake from enteral and parenteral sources in preterm infants; Nutritional requirements during the transition period of the infants; Strategies in feeding to prevent necrotizing enterocolitis.

  • Enteral feeding practices in preterm infants in South Africa. Raban, M. S.; Joolay, Y.; Horn, A. R.; Harrison, M. C. // South African Journal of Child Health;Feb2013, Vol. 7 Issue 1, p8 

    Background. Optimal feeding regimens in babies weighing <1000 g have not been established, and wide variations occur. In South Africa (SA) this situation is complicated by varied resource constraints. Objective. To determine the preterm enteral feeding practices of paediatricians in SA. Methods....

  • The Relationship between Glucagon-Like Peptide 2 and Feeding Intolerance in Preterm Infants. OZER, ESRA ARUN; HOLST, JENS JUUL; DUMAN, NURAY; KUMRAL, ABDULLAH; OZKAN, HASAN // Journal of Tropical Pediatrics;Aug2009, Vol. 55 Issue 4, p276 

    Glucagon-like peptide 2 (GLP-2) is a hormone produced primarily in the distal intestine, stimulated by enteral nutrients, and playing diverse roles in the intestinal adaptation and growth. We aimed to investigate whether GLP-2 may play a role in the development of feeding intolerance which is a...

  • Very early feeding in stable small for gestational age preterm infants: a randomized clinical trial. Arnon, Shmuel; Sulam, Daniella; Konikoff, Fred; Regev, Rivka H.; Litmanovitz, Ita; Naftali, Timna // Jornal de Pediatria;Jul/Aug2013, Vol. 89 Issue 4, p388 

    Objective: To examine the effect of initiating very early feeding on time-to-reach full feeding in stable, small for gestational age (SGA) preterm infants. Method: Preterm infants with gestational age below 37 weeks and birth weight below the 10th percentile were randomly allocated to a very...

  • Gut mucosal and plasma concentrations of glutamine: a comparison between two enriched enteral feeding solutions in critically ill patients. Preiser, Jean-Charles; Peres-Bota, Daliana; Eisendrath, Pierre; Vincent, Jean-Louis; Van Gossum, André // Nutrition Journal;2003, Vol. 2, p13 

    Background: Addition of glutamine to enteral nutrition formulas is consistently associated with a significant decrease in septic morbidity in critically ill patients, possibly related to the attenuation of gut dysfunction. This pilot study was undertaken to compare the effects of enteral...

  • hyperalimentation.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1111 

    An encyclopedia entry for the medical term "hyperalimentation" is presented. It refers to the enteral and parenteral infusion of a solution containing sufficient amino acids, glucose, fatty acids, and vitamins and minerals to sustain life. Information is also presented on patient care, including...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics