Review: The cosyntropin-stimulation test has limited value for detecting and excluding adrenal insufficiency

January 2004
ACP Journal Club;Jan/Feb2004, Vol. 140 Issue 1, p18
Academic Journal
This article focuses on a study regarding diagnosis of adrenal insufficiency (AI), published in the 2003 issue of the journal "Annals of Internal Medicine." For this study researchers selected studies if they were published in English, evaluated the diagnosis of primary AI or secondary AI. 4 studies on primary AI and 29 studies on secondary AI were included. Cortisol cutpoints for the diagnosis of primary and secondary AI were measured. The study concluded that cosyntropin-stimulation tests have similar diagnostic properties. The cosyntropin test may be useful for detecting, but not for excluding, secondary AI.


Related Articles

  • Review: The cosyntropin-stimulation test has limited value for detecting and excluding adrenal insufficiency: COMMENTARY. Montori, Victor M. // ACP Journal Club;Jan/Feb2004, Vol. 140 Issue 1, p18 

    This article focuses on a study regarding diagnosis of adrenal insufficiency (AI), published in the 2003 issue of the journal "Annals of Internal Medicine." Systematic reviews may provide highly precise estimates of the properties of diagnostic tests. These reviews can offer evidence of...

  • Monitoring Growth in asthmatic children treated with high dose inhaled glucocorticoids does not predict adrenal suppression. Dunlop, K. A.; Carson, D. J.; Steen, H. J.; McGovern, V.; McNaboe, J.; Shields, M. D. // Archives of Disease in Childhood;Aug2004, Vol. 89 Issue 8, p713 

    Aims: To determine whether routine outpatient monitoring of growth predicts adrenal suppression in prepubertal children treated with high dose inhaled glucocorticoid. Methods: Observational study of 35 prepubertal children (aged 4-10 years) treated with at least 1000 pg/day of inhaled budesonide...

  • Glucocorticoids. Adcock, Ian M. // Encyclopedic Reference of Molecular Pharmacology;2004, p411 

    A definition of the term "glucocorticoids" is presented. The most important function of glucocorticoids in disease is to regulate the inflammatory response to exogenous stimuli. Endogenous glucocorticoids are released from the zona fasiculata of the adrenal gland in response to stress. Exogenous...

  • Clinical Potencies of Glucocorticoids: What do we Really Measure? Dubois, Emile F. L. // Current Respiratory Medicine Reviews;2005, Vol. 1 Issue 1, p103 

    Glucocorticoids (GC) are used in pulmonary medicine since the early nineteen-thirties; in the beginning by using extracts of adrenal glands of animals, later on synthetically composed and since the early nineteen-seventies in inhaled formulation. In pulmonary medicine the majority of...

  • Glucocorticoids Play a Key Role in Circadian Cell Cycle Rhythms. Dickmeis, Thomas; Lahiri, Kajori; Nica, Gabriela; Vallone, Daniela; Santoriello, Cristina; Neumann, Carl J.; Hammerschmidt, Matthias; Foulkes, Nicholas S. // PLoS Biology;Apr2007, Vol. 5 Issue 4, p0854 

    Clock output pathways play a pivotal role by relaying timing information from the circadian clock to a diversity of physiological systems. Both cell-autonomous and systemic mechanisms have been implicated as clock outputs; however, the relative importance and interplay between these mechanisms...

  • Targeting the Hemoglobin Scavenger receptor CD163 in Macrophages Highly Increases the Anti-inflammatory Potency of Dexamethasone. Graversen, Jonas H; Svendsen, Pia; Dagnæs-Hansen, Frederik; Dal, Jakob; Anton, Gabriele; Etzerodt, Anders; Petersen, Mikkel D; Christensen, Peter A; Møller, Holger J; Moestrup, Søren K // Molecular Therapy;Aug2012, Vol. 20 Issue 8, p1550 

    Synthetic glucocorticoids are potent anti-inflammatory drugs but serious side effects such as bone mobilization, muscle mass loss, immunosuppression, and metabolic alterations make glucocorticoid therapy a difficult balance. The therapeutic anti-inflammatory effect of glucocorticoids relies...

  • Misoprostol reduces GI complications of chronic NSAID use.  // Geriatrics;Nov95, Vol. 50 Issue 11, p61 

    Presents abstracts from articles by Silverstein et al and Raskin et al on the ability of misoprostol in reducing the gastrointestinal complications in patients taking nonsteroidal anti-inflammatory drugs published in the `Annals of Internal Medicine' periodical.

  • Prevention of NSAID-induced ulcers with misoprostol.  // American Family Physician;12/1/1995, Vol. 52 Issue 8, p2345 

    Reports on a study on the prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced ulcers with misoprostol, as presented in the September 1, 1995 issue of `Annals of Internal Medicine.' Profile and treatment of patients in the study; Finding that misoprostol can provide significant...

  • Unnecessary Prescribing of NSAIDs and Management of NSAID-Related Gastropathy. Hinchey, Kevin T. // Cortlandt Forum;Sep98, Vol. 11 Issue 9, p59 

    Analyzes the article regarding the unnecessary prescription of nonsteroidal anti-inflammatory drugs (NSAID) and management of NSAID-related gastropathy, which appeared in the 1997 issue of the `Annals Internal Medicine.' Chances of prescribing an NSAID.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics