Review: Anticholinergic drugs improve motor function and disability in Parkinson disease: COMMENTARY

Holloway, Robert; Frank, Sam
January 2004
ACP Journal Club;Jan/Feb2004, Vol. 140 Issue 1, p15
Academic Journal
This article focuses on a study regarding anticholinergics for symptomatic management of parkinson's disease (PD), published in the 2003 issue of the journal "Cochrane Database of Systematic Reviews." In the authors' opinion, the study reminds us that most of what we do in medicine is based on nonrandomized studies and clinical experience. The authors say that clinical trials included in the study are old, heterogeneous, and of such poor quality that only limited conclusions can be drawn. Most patients with PD can be managed without anticholinergics, but if one chooses to use them, they should be used primarily to treat troubling parkinsonian tremor, either as initial treatment or if tremor continues to be bothersome despite dopaminergic therapy.


Related Articles

  • Review: Anticholinergic drugs improve motor function and disability in Parkinson disease.  // ACP Journal Club;Jan/Feb2004, Vol. 140 Issue 1, p15 

    This article focuses on a study regarding anticholinergics for symptomatic management of parkinson's disease (PD), published in the 2003 issue of the journal "Cochrane Database of Systematic Reviews." For this study the researchers selected studies if they were randomized controlled trials that...

  • benztropine mesilate.  // Royal Society of Medicine: Medicines;2002, p108 

    The article presents information on benztropine mesilate, an anticholinergic drug used in the treatment of some types of parkinsonism. It increases mobility and decreases rigidity and tremor, and the tendency to produce an excess of saliva is also reduced, but it has only a limited effect on...

  • Surgery for ParkinsonÂ’s disease: lack of reliable clinical trial evidence. R.L. Stowe; K. Wheatley; C.E. Clarke; N.J. Ives; R.K. Hills; A.C. Williams; J.P. Daniels; R. Gray // Journal of Neurology, Neurosurgery & Psychiatry;Apr2003, Vol. 74 Issue 4, p519 

    There has been a striking resurgence of interest in surgery for Parkinson's disease (PD) with new targets identified and new procedures developed. This systematic review identified over 500 studies of surgery for PD published since 1990, including over 10 000 patients. However, the authors were...

  • Where do we stand in the treatment of Parkinson's disease? Mizuno, Yoshikuni // Journal of Neurology;Sep2007, Vol. 254 Issue S5, p13 

    This article reviews the current situation regarding the treatment of Parkinson's disease (PD). How to apply the various therapeutic options to treat PD appears to be internationally agreed, but the currently available treatment methods are said to be all symptomatic ones. However, some of these...

  • Atypical parkinsonism in Guadeloupe: a common risk factor for two closely related phenotypes? Annie Lannuzel; G. U. Höglinger; S. Verhaeghe; L. Gire; S. Belson; M. Escobar-Khondiker; P. Poullain; W. H. Oertel; E. C. Hirsch; B. Dubois; M. Ruberg // Brain: A Journal of Neurology;Mar2007, Vol. 130 Issue 3, p816 

    In Guadeloupe, there is an abnormally high frequency of atypical parkinsonism. Only one-third of the patients that develop parkinsonian symptoms were reported to present the classical features of idiopathic Parkinson disease and one-third a syndrome resembling progressive supranuclear palsy...

  • Managing Parkinson's disease. Robinson, Gina // Independent Nurse;2/15/2010, p21 

    The article discusses Parkinson's disease, which is a degenerative neurological disease that affects 120,000 individuals in Great Britain aged 55-60 years old. Unilateral resting tremors, slowness and poor balance are among the symptoms of Parkinson's disease and its diagnosis is usually based...

  • The L-dopa response in vascular parkinsonism. Zijlmans J C M; Katzenschlager R; Daniel S E; Lees A J L; Zijlmans, J C M; Katzenschlager, R; Daniel, S E; Lees, A J L // Journal of Neurology, Neurosurgery & Psychiatry;Apr2004, Vol. 75 Issue 4, p545 

    Objective: To determine whether a positive L-dopa response in vascular parkinsonism (VP) is correlated with the presence of nigrostriatal pathology due to either vascular damage or neuronal cell loss.Methods: Seventeen patients with pathologically confirmed VP were...

  • Timing the initiation of treatment in Parkinson's disease. Grosset, Donald G.; Schapira, Anthony H. // Journal of Neurology, Neurosurgery & Psychiatry;Jun2008, Vol. 79 Issue 6, p615 

    The article presents views and insights of the author concerning the timing in the initiation of treatment in Parkinson's disease (PD). Clinical, imaging and pathological studies suggest that the cell loss begins 7 to 10 years before the onset of clinical features sufficient to allow the...

  • The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson’s disease. D Aarsland // Journal of Neurology, Neurosurgery & Psychiatry;Aug2009, Vol. 80 Issue 8, p928 

    BACKGROUND: Neuropsychiatric symptoms are common in Parkinson’s disease (PD) and have important clinical consequences for patients, caregivers and society. Few studies of neuropsychiatric symptoms in early untreated PD exist. OBJECTIVE: To explore the range, clustering and correlates of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics