Review: Omalizumab reduces asthma exacerbations and daily steroid use

January 2004
ACP Journal Club;Jan/Feb2004, Vol. 140 Issue 1, p13
Academic Journal
This article focuses on a study regarding anti-immunoglobulin E for chronic asthma, published in the 2003 issue of the journal "Cochrane Database of Systematic Reviews." For this study the researchers selected studies if they were randomized controlled trials comparing anti-immunoglobulin E at any dose or route with placebo or conventional treatments. Main outcomes were reduction or termination of steroid use and asthma exacerbations. 8 blinded, placebo-controlled trials met the inclusion criteria. Omalizumab drug was administered by inhaler in 1 trial, intravenously in 3 trials, and subcutaneously in 4 trials. The study concluded that in patients with asthma, intravenous or subcutaneous omalizumab reduces asthma exacerbations when used as adjunctive or steroid-sparing therapy and reduces inhaled steroid use.


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