Review: Lower-dose combination antihypertensive therapy is preferable to standard-dose single-drug therapy: COMMENTARY

Linden, Wolfgang
January 2004
ACP Journal Club;Jan/Feb2004, Vol. 140 Issue 1, p4
Academic Journal
This article focuses on a study related to value of low dose combination treatment with blood pressure-lowering drugs, published in the 2003 issue of "British Medical Journal." The valuable and well-researched study investigates the effectiveness of the 5 most frequently used drugs for pharmacologic treatment of hypertension. This study is useful to guide practitioners in making empirically based prescription decisions that balance drug effectiveness with minimal side effects, to help policy makers in identifying similarly effective drugs so that maximum patient benefit can be achieved at the lowest cost. The careful investigation and display of dose-response curves and corresponding increases in side effects will be much appreciated by practitioners, and the huge patient base underlying these numbers speaks for the trustworthiness of the findings.


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