Review: Lower-dose combination antihypertensive therapy is preferable to standard-dose single-drug therapy

January 2004
ACP Journal Club;Jan/Feb2004, Vol. 140 Issue 1, p4
Academic Journal
This article focuses on a study related to value of low dose combination treatment with blood pressure lowering drugs, published in the 2003 issue of "British Medical Journal." For the study, 354 trials met the selection criteria. The trials included 791 treatment groups that tested different drugs or different doses of the same drug. Data were synthesized by meta-analysis. The 5 drug categories gave similar blood pressure reductions. 50 trials tested the effect of drugs of 2 categories separately and in combination. The blood pressure-lowering effects of different drug categories were additive. The study concludes that when drugs are used in combination, the blood pressure reductions are additive but the adverse effects are less than additive.


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