Review: Low-dose diuretics are the best first-line antihypertensive therapy: COMMENTARY

Davidson, Richard A.
January 2004
ACP Journal Club;Jan/Feb2004, Vol. 140 Issue 1, p3
Academic Journal
This article focuses on a study related to health outcomes associated with various antihypertensive therapies used as first-line agents, published in the 2003 issue of "Journal of the American Medical Association." The author says that diuretics should be the initial treatment for most hypertensive persons. The study attempts to add to medical literature by using a methodologically complex method, the network meta-analysis. The advantage of this technique over a traditional meta-analysis is to combine direct comparisons with indirect comparisons of drugs. Despite the fact that the study provides several alternative analytic designs, the results were consistent with most other direct studies showing that diuretics were unsurpassed in decreasing cardiovascular risk outcomes compared with other treatments.


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