Review: Low-dose diuretics are the best first-line antihypertensive therapy

January 2004
ACP Journal Club;Jan/Feb2004, Vol. 140 Issue 1, p3
Academic Journal
This article focuses on a study related to health outcomes associated with various antihypertensive therapies used as first-line agents, published in the 2003 issue of "Journal of the American Medical Association." Two investigators independently extracted data on patients, interventions, and outcomes. Outcomes were coronary heart disease, fatal and nonfatal stroke, fatal and nonfatal congestive heart failure and total mortality. Analysis was done using network meta-analysis, which combined all available comparisons both within and between trials. The study concluded that in patients with hypertension, low-dose diuretics are as effective as first-line therapy in preventing major cardiovascular disease endpoints.


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