Importance of internal mammary artery perfusion in cardiac ischemia and reperfusion

Ege, Turan; Eskiocak, Sevgi; Yuksel, Volkan; Taskiran, Ali; Duran, Enver
November 2003
Perfusion;Nov2003, Vol. 18 Issue 6, p351
Academic Journal
Purpose: Our purpose was to investigate the changes in antioxidant defense systems due to internal mammary artery (IMA) perfusion during coronary artery bypass graft (CABG) operations in which proximal anastomoses were completed under partial bypass with the aid of a side-biting clamp. Material and Method: Twenty-five patients to be studied were divided into two groups according to the criterion of whether during proximal anastomoses left internal mammary artery (LIMA) perfusion was applied (n = 15, LIMA group) or not (n = 10, non-LIMA group). The erythrocyte catalase (CAT), superoxide dismutase (SOD), serum lipid peroxidation (LPO) products and whole blood reduced glutathione (GSH) levels were measured in the blood samples taken from the coronary sinus before cardiopulmonary bypass (CPB) (t[sub 1]), before declamping (t[sub 2]), at the 5th min after declamping (t[sub 3]), at the 5th (t[sub 4]) and 15th (t[sub 5]) min after removing the side-biting clamp. Results: While erythrocyte CAT enzyme activity decreases in both groups after the basal measurements, no significant difference was detected between the groups. Although the GSH levels did not differ at t[sub 1], t[sub 2] and t[sub 3], they were found to be higher in the LIMA group at t[sub 4] (p = 0.006) and t[sub 5] (p = 0.021). The erythrocyte SOD enzyme activity decreased after the basal measurements in both groups, but this reduction was less in the LIMA group at t[sub 4] (p = 0.034) and t[sub 5] (p = 0.018) compared to the other group. LPO products rose in both groups when reperfusion started after declamping. The levels of LPO products were significantly higher at t[sub 4] and t[sub 5] in the non-LIMA group than the other group (p = 0.011 and p = 0.008). Conclusion: If proximal anastomoses of coronary grafts are completed under partial bypass, permitting LIMA perfusion during this procedure will be beneficial to antioxidant defense systems.


Related Articles

  • Obliteration of the Mediastinal Pleural "Sac" in Internal Mammary Artery Coronary Bypass. Gatzinsky, Pantalei; Al Khaja, Najib // Vascular Surgery;May1992, Vol. 26 Issue 4, p253 

    A technique for avoiding angulation of the internal mammary artery and tension over the mammary-coronary anastomosis caused by the lung is described.

  • Síndrome do roubo coronário-subclávio: relato de caso e revisão da literatura. Miiller, Jean Carlo; Candemil, Patrick Cardoso; da Rocha Loures, João Marcelo Goncalves; Zucco, Fabrício Martins; Belz, Walmor Erwin; da Rocha Loures, Nilceu Gomes; Ortiz, Marco Rodrigo; Garcia, Rogério Sanchez // Jornal Vascular Brasileiro;Mar2012, Vol. 11 Issue 2, p166 

    The phenomenon of coronary-subclavian steal is defined as the reversed blood flow in a coronary artery, through internal mammary artery graft towards medial-distal subclavian artery, which happens due to severe stenosis or total occlusion of the proximal portion of the latter. It is a rare but...

  • Coronary Artery Bypass Grafting In A Patient With Dextrocardia With Situs Inversus: A Case Report. Tarhan, Arif; Arslan, Yücesin Yücesin; Kehlibar, Tamer; Özler, Azmi // Internet Journal of Thoracic & Cardiovascular Surgery;2005, Vol. 7 Issue 2, p4 

    We present a 47 year old male patient with dextrocardia and situs inversus who underwent successful coronary artery bypass with cardiopulmonary bypass. Vessels revascularized included the left internal mammary artery to the left anterior descending artery, the right internal mammary artery to...

  • Evaluation of Flow Characteristics of the Left Internal Thoracic Artery Graft. Cagli, Kerim; Emir, Mustafa; Kunt, Aysegul; Ergun, Kumral; Tola, Muharrem; Topbas, Murat; Vural, Kerem; Sener, Erol // Texas Heart Institute Journal;2004, Vol. 31 Issue 4, p376 

    Reports on a study which dealt with the evaluation of the flow characteristics of the left internal thoracic artery (LITA). Use of the LITA in coronary artery bypass; Study subjects; Measurement of total flow volume using the free-bleeding technique; Advantages of transthoracic color Doppler...

  • Effects of Previously Well-Developed Collateral Vessels. Ozdemir, Ozcan; Ozkan, Deniz Ozdemirel; Soylu, Mustafa; Demir, Ahmet Duran; Alyan, Omer; Geyik, Bilal; Aras, Dursun; Kunt, Aysegul; Arda, Kemal; Sasmaz, Hatice; Cobanoglu, Adnan // Texas Heart Institute Journal;2005, Vol. 32 Issue 1, p35 

    Transthoracic Doppler ultrasonography can assess left internal mammary artery patency and flow after coronary artery bypass grafting. We aimed to show, by transthoracic Doppler ultrasonography, the early effects upon left internal mammary artery graft flow of preoperative collateral vessels...

  • Noradrenaline-induced contraction of human saphenous vein and human internal mammary artery: involvement of different α-adrenoceptor subtypes. Giessler, Christine; Wangemann, Thekla; Silber, Rolf-Edgar; Dhein, Stefan; Brodde, Otto-Erich // Naunyn-Schmiedeberg's Archives of Pharmacology;Aug2002, Vol. 366 Issue 2, p104 

    Although saphenous veins and internal mammary arteries are commonly used for coronary artery bypass grafting, only a very few comparative studies are available on α-adrenoceptor-mediated vasoconstriction in these vessels. Thus, we determined, in isolated rings from human saphenous vein and...

  • Free Internal Mammary Artery Graft as Arteriovenous Fistula: An Experimental Study. Harjula, A.; Lehtola, A.; Sariola, H.; Mattila, S.; Aarnio, P. // Vascular Surgery;May/Jun1988, Vol. 22 Issue 3, p172 

    To evaluate the behavior of the free internal mammary artery (IMA) graft in coronary bypass surgery an experiment was carried out in canine arteriovenous shunt position. From 6 dogs the IMA was dissected free from the right side as a naked artery and from the left side with the 2-cm-wide...

  • Left subclavian artery stenosis with subclavian -- subclavian bypass. Roguin, A.; Heldman, A. W.; Riley, R. D.; Alhadaad, I. A. // Heart;Mar2005, Vol. 91 Issue 3, p372 

    The article presents a medical case where an arch aortography demonstrates an occluded brachiocephalic trunk and subclavian-subclavian bypass graft (SSBG) in a 56 year, old woman with left main and triple coronary artery disease requiring coronary artery bypass graft (CABG) surgery. A selective...

  • Koroner Arter Bypass Operasyonlarinda Kullanilan Arteriyel ve Venöz Greftlerin Ä°ntraoperatif Akim Ölçüm Teknikleri ile DeÄŸerlendirilmesi.  // Medical Journal of Trakya University / Trakya Universitesi Tip F;2010, Vol. 27 Issue 4, p411 

    No abstract available.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics