TITLE

Improvement in Lipoatrophy Associated with Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus--Infected Patients Switched from Stavudine to Abacavir or Zidovudine: The Results of the TARHEEL Study

AUTHOR(S)
McComsey, Grace A.; Ward, Douglas J.; Hessenthaler, Siegrid M.; Sension, Michael G.; Shalit, Peter; Lonergan, J. Tyler; Fisher, Robin L.; Williams, Vanessa C.; Hernandez, Jaime E.
PUB. DATE
January 2004
SOURCE
Clinical Infectious Diseases;1/15/2004, Vol. 38 Issue 2, p263
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Stavudine use is a contributing factor for lipoatrophy, whereas use of abacavir or zidovudine is less likely to cause this complication. The TARHEEL study was a 48-week, open-label study that assessed changes in lipoatrophy after abacavir (86 patients [73%]) or zidovudine (32 patients [27%]), 300 mg twice daily, was substituted for stavudine for 118 human immunodeficiency virus (HIV)—infected patients (HIV type 1 RNA level, <400 copies/mL) with virological suppression who had developed lipoatrophy after ≥6 months of stavudine-based treatment. At week 48, full-body dual-energy x-ray absorptiometry demonstrated a median increase in arm fat of 35%, leg fat of 12%, and trunk fat of 18%, compared with the baseline level. These improvements coincided with fat gain in lipoatrophic areas that was documented by computerized tomography. Results of a ’body image’ questionnaire showed that a substantial percentage of patients reported some or a lot of fat gain in the arms (22%), legs (18%), buttocks (19%), and face (27%). HIV suppression was maintained over the study period. In conclusion, replacing stavudine with abacavir or zidovudine resulted in improvement in stavudine-induced lipoatrophy.
ACCESSION #
12082199

 

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