TITLE

CD38 Expression in CD8 + T Cells Predicts Virological Failure in HIV Type 1--Infected Children Receiving Antiretroviral Therapy

AUTHOR(S)
Resino, Salvador; Bellón, José M.; Gurbindo, M. Dolores; Muñoz-Fernández, M. Ángeles
PUB. DATE
February 2004
SOURCE
Clinical Infectious Diseases;2/1/2004, Vol. 38 Issue 3, p412
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An observational study of children vertically infected with human immunodeficiency virus type 1 (HIV-1) was performed to determine the role of CD38 expression in CD8[sup+] T cells as prognostic marker of virological failure in children receiving HAART. We studied 42 children who were receiving antiretroviral therapy and who had an undetectable virus load (uVL), and we found a negative correlation between CD38 expression in CD8[sup+] T cells and the duration of uVL. We selected 17 HIV-1­infected children with CD38 values close to the baseline level (i.e., the first uVL achieved), and we distributed the children into 2 groups on the basis of median CD38 value in CD8[sup+] T cells. Children with CD38 values in CD8[sup+] T cells that were higher than the median had a higher incidence and relative risk of virological failure than did those with values lower than the median. In conclusion, we demonstrate for the first time that CD8[sup+]CD38[sup+] T cell count is a good prognostic marker of therapeutic failure in HIV-1­infected children.
ACCESSION #
12080814

 

Related Articles

  • Predicting differential responses to structured treatment interruptions during HAART Bajaria, Seema H.; Webb, Glenn; Kirschner, Denise E. // Bulletin of Mathematical Biology;Sep2004, Vol. 66 Issue 5, p1093 

    Highly active antiretroviral therapy (HAART) has been used clinically in various administration schemes for several years. However, due to the development of drug resistance, evolution of viral strains, serious side effects, and poor patient compliance, the combination of drugs used in HAART...

  • Use of Multisystemic Therapy to Improve Antiretroviral Adherence and Health Outcomes in HIV-Infected Pediatric Patients: Evaluation of a Pilot Program. Ellis, Deborah A.; Naar-King, Sylvie; Cunningham, Phillippe B.; Secord, Elizabeth // AIDS Patient Care & STDs;Feb2006, Vol. 20 Issue 2, p112 

    The purpose of the current study was to evaluate a clinical program that used multisystemic therapy (MST) to improve regimen adherence and health outcomes among children with perinatally acquired HIV who exhibited high viral loads in the absence of viral resistance. MST is an intensive,...

  • Enfuvirtide: A Review of its Use in the Management of HIV Infection. Oldfield, Vicki; Keating, Gillian M.; Plosker, Greg // Drugs;2005, Vol. 65 Issue 8, p1139 

    Enfuvirtide (Fuzeon®), a fusion inhibitor, is indicated in combination with other antiretroviral agents in the treatment of HIV infection in treatment-experienced adults and children aged >6 years. The addition of subcutaneous enfuvirtide to an optimised antiretroviral background regimen...

  • Expression of human granulocyte-colony stimulating factor (hG-CSF) gene in tobacco (Nicotiana tabacum). Tabar, Mehdi Sharifi; Solouki, Mahmood; Tohidfar, Masoud; Sadeghizadeh, Majid // Australian Journal of Crop Science;2012, Vol. 6 Issue 1, p135 

    Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family that regulates hematopoietic cell proliferation and differentiation. In this research, Tobacco (Nicotianatabacum L., var. NC-2512) leaf disc explants were transformed with Agrobacterium tumefaciens (LBA4404 strain),...

  • Antiviral Briefs.  // AIDS Patient Care & STDs;Apr2005, Vol. 19 Issue 4, p272 

    This article presents news related to antiviral agents. Patients receiving the fusion inhibitor enfuvirtide continue to derive clinical and immunological benefit from the drug even when viremia persists. Spanish researchers in Madrid found that, during treatment with the fusion inhibitor,...

  • Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection. Brooks, David G.; McGavern, Dorian B.; Oldstone, Michael B. A. // Journal of Clinical Investigation;Jun2006, Vol. 116 Issue 6, p1675 

    Failure to clear persistent viral infections results from the early loss of T cell activity. A pertinent question is whether the immune response is programmed to fail or if nonresponsive T cells can specifically be fixed to eliminate infection. Although evidence indicates that T cell expansion...

  • Antifungal and Antiparasitic Activities of Lactoferrin. Leboffe, Loris; Giansanti, Francesco; Antonini, Giovanni // Anti-Infective Agents in Medicinal Chemistry;2009, Vol. 8 Issue 2, p114 

    The first function attributed to lactoferrin, an iron-binding protein belonging to the non-immune natural defences, was antimicrobial activity related to its capability of sequestering iron. Many other antimicrobial and antiviral functions have been ascribed to lactoferrin. In vitro activity...

  • Effect ofOenanthe javanicaflavone on human and duck hepatitis B virus infection. Wei-Na Wang; Xin-Bo Yang; He-Zhi Liu; Zheng-Ming Huang; Guang-Xia Wu // Acta Pharmacologica Sinica;May2005, Vol. 26 Issue 5, p587 

    To study the antiviral effect ofOenanthe javanicaflavones (OjF) on human hepatoma HepG2.2.15 culture system and duck hepatitis B virus (DHBV) infection.(1) After incubation for 24 h, the 2.2.15 cells were treated with different concentrations ofOjF for 12 d. The cell alteration was observed by...

  • In vivo and in vitro antiviral activity of hyperoside extracted from Abelmoschus manihot (L) medik. Lin-lin Wu; Xin-bo Yang; Zheng-ming Huang; He-zhi Liu; Guang-xia Wu // Acta Pharmacologica Sinica;Mar2007, Vol. 28 Issue 3, p404 

    Aim: To assess the anti-hepatitis B virus (HBV) effect of hyperoside extracted from Abelmoschus manihot (L) medik. Methods: The human hepatoma Hep G2.2.15 cell culture system and duck hepatitis B virus (DHBV) infection model were used as in vivo and in vitro models to evaluate the anti-HBV...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics