TITLE

A Microsatellite Variability Screen for Positive Selection Associated With the "Out of Africa" Habitat Expansion of Drosophila melanogaster

AUTHOR(S)
Kauer, M.O.; Dieringer, D.; Schlötterer, C.
PUB. DATE
November 2003
SOURCE
Genetics;Nov2003, Vol. 165 Issue 3, p1137
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We report a "hitchhiking mapping" study in D. melanogaster, which searches for genomic regions with reduced variability. The study's aim was to identify selective sweeps associated with the "out of Africa" habitat expansion. We scanned 103 microsatellites on chromosome 3 and 102 microsatellites on the X chromosome for reduced variability in non-African populations. When the chromosomes were analyzed separately, the number of loci with a significant reduction in variability only slightly exceeded the expectation under neutrality—six loci on the third chromosome and tour loci on the X chromosome. However, non-African populations also have a more pronounced average loss in variability on the X chromosomes as compared to the third chromosome, which suggests the action of selection. Therefore, comparing the X chromosome to the autosome yields a higher number of significantly reduced loci. However, a more pronounced loss of variability on the X chromosome may be caused by demographic events rather than by natural selection. We therefore explored a range of demographic scenarios and found that some of these captured most, but not all aspects of our data. More theoretical work is needed to evaluate how demographic events might differentially affect X chromosomes and autosomes and to estimate the most likely scenario associated with the out of Africa expansion of D. melanogaster.
ACCESSION #
12076012

 

Related Articles

  • The Drosophila melanogaster Genetic Reference Panel. Mackay, Trudy F. C.; Richards, Stephen; Stone, Eric A.; Barbadilla, Antonio; Ayroles, Julien F.; Zhu, Dianhui; Casillas, Sònia; Han, Yi; Magwire, Michael M.; Cridland, Julie M.; Richardson, Mark F.; Anholt, Robert R. H.; Barrón, Maite; Bess, Crystal; Blankenburg, Kerstin Petra; Carbone, Mary Anna; Castellano, David; Chaboub, Lesley; Duncan, Laura; Harris, Zeke // Nature;2/9/2012, Vol. 482 Issue 7384, p173 

    A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation...

  • Consequences of Recombination Rate Variation on Quantitative Trait Locus Mapping Studies:.... Noor, Mohamed A.F.; Cunningham, Aimee L.; Larkin, John C. // Genetics;Oct2001, Vol. 159 Issue 2, p581 

    Examines the effect of variation in gene density per centimorgan on quantitative trait locus (QTL) mapping using data from Drosophila melanogaster genome. Correlation between centromeres and autosomes; Impact of autosomes on X chromosome of D. melanogaster; Relevance of chromosome in...

  • Molecular and cytogenetical characterization of the 10A1-2 band and adjoining region in the... Yu Kozlova, T.; Semeshin, V.F. // Genetics;Mar94, Vol. 136 Issue 3, p1063 

    Presents a molecular and cytogenetical characterization of the 10A1-2 band and adjoining region in the Drosophila melanogaster polytene X chromosome. Mapping of new chromosome rearrangements; Cloning; Mapping of the genes.

  • A microsatellite linkage map of Drosophila mojavensis. Staten, Regina; Schully, Sheri Dixon; Noor, Mohamed A. F. // BMC Genetics;2004, Vol. 5, p1 

    Background: Drosophila mojavensis has been a model system for genetic studies of ecological adaptation and speciation. However, despite its use for over half a century, no linkage map has been produced for this species or its close relatives. Results: We have developed and mapped 90...

  • Geographic Patterns of Genome Admixture in Latin American Mestizos. Sijia Wang; Ray, Nicolas; Rojas, Winston; Parra, Maria V.; Bedoya, Gabriel; Gallo, Carla; Poletti, Giovanni; Mazzotti, Guido; Hill, Kim; Hurtado, Ana M.; Camrena, Beatriz; Nicolini, Humberto; Klitz, William; Barrantes, Ramiro; Molina, Julio A.; Freimer, Nelson B.; Bortolini, Maria Cátira; Salzano, Francisco M.; Petzl-Erler, Maria L.; Tsuneto, Luiza T. // PLoS Genetics;Mar2008, Vol. 4 Issue 3, p1 

    The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of...

  • Multiple Signatures of Positive Selection Downstream of Notch on the X Chromosome in Drosophila melanogaster. DuMont, Vanessa Bauer; Aquadro, Charles F. // Genetics;Oct2005, Vol. 171 Issue 2, p639 

    To identify genomic regions affected by the rapid fixation of beneficial mutations (selective sweeps), we performed a scan of microsatellite variability across the Notch locus region of Drosophila melanogaster Nine microsatellites spanning 60 kb of the X chromosome were surveyed for variation in...

  • Investigating Natural Variation in Drosophila Courtship Song by the Evolve and Resequence Approach. Turner, Thomas L.; Miller, Paige M. // Genetics;Jun2012, Vol. 191 Issue 2, p633 

    A primary goal of population genetics is to determine the genetic basis of natural trait variation. We could significantly advance this goal by developing comprehensive genome-wide approaches to link genotype and phenotype in model organisms. Here we combine artificial selection with...

  • Strong Regional Heterogeneity in Base Composition Evolution on the Drosophila X Chromosome. Ko, Wen-Ya; Piao, Shengfu; Akashi, Hiroshi // Genetics;Sep2006, Vol. 174 Issue 1, p349 

    Fluctuations in base composition appear to be prevalent in Drosophila and mammal genome evolution, but their timescale, genomic breadth, and causes remain obscure. Here, we study base composition evolution within the X chromosomes of Drosophila melanogaster and five of its close relatives....

  • Genomic imprinting and position-effect variegation in Drosophila melanogaster. Lloyd, Vett K.; Sinclair, Don A. // Genetics;Apr99, Vol. 151 Issue 4, p1503 

    Analyzes genomic imprinting and position-effect variegation in a mini-X chromosome in Drosophila melanogaster. Difference in imprinting when genes are transmitted by male or female parent; Effect of factors that modify position-effect variegation on somatic expression; Importance of chromatin...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics