TITLE

Significance of R1-resection at the bronchial margin after surgery for non-small-cell lung cancer

AUTHOR(S)
Geun Dong Lee; Dong Kwan Kim; Se Jin Jang; Se Hoon Choi; Hyeong Ryul Kim; Yong-Hee Kim; Park, Seung-Il
PUB. DATE
January 2017
SOURCE
European Journal of Cardio-Thoracic Surgery;Jan2017, Vol. 51 Issue 1, p176
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: We aimed to evaluate the significance of microscopic residual disease at the bronchial resection margin (R1-BRM) after curative surgery for non-small cell lung cancer (NSCLC). METHODS: Retrospective review was performed on 1800 patients from 1994 to 2012. We compared recurrence and survival between 1740 patients with R0-resection at the BRM (R0-BRM) and 60 patients with R1-resection at the BRM (R1-BRM), comprising 18 cases of mucosal carcinoma in situ (R1-CIS) and 42 cases of extramucosal residual disease (R1-EMD). RESULTS: Stump recurrence occurred in 43 patients. The 5-year cumulative incidence of stump recurrence in group R0, R1-CIS and R1-EMD was 3.1, 5.6 and 12.2%, respectively. Significant differences of stump recurrence were observed between the groups (R0 versus R1-CIS, P = 0.008; R0 versus R1-EMD, P = 0.007). In Stage IB or II disease, the overall survival rate for R1-EMD was significantly lower than that for R0-BRM (P = 0.014), whereas the difference in overall survival rate between the R1-CIS group and the R0-BRM was not significant (P = 0.37). In Stage IIIA disease, the overall survival rates for R1-CIS (P = 0.87) and R1-EMD (P = 0.45) were not significantly different from that for R0-BRM. CONCLUSIONS: R1-BRM comprises a higher rate of stump recurrence, compared with that of R0-BRM. Herein, R1-EMD was associated with poor overall survival in Stage IB/II disease. In Stage IIIA disease, R1-BRM showed similar overall survival rate to that for R0-BRM, although the number of patients was too small to draw definitive conclusions thereon.
ACCESSION #
120713102

 

Related Articles

  • Lymph Node Metastases and Prognosis in Left Upper Division Non-Small Cell Lung Cancers: The Impact of Interlobar Lymph Node Metastasis. Kuroda, Hiroaki; Sakao, Yukinori; Mun, Mingyon; Uehara, Hirofumi; Nakao, Masayuki; Matsuura, Yousuke; Mizuno, Tetsuya; Sakakura, Noriaki; Motoi, Noriko; Ishikawa, Yuichi; Yatabe, Yasushi; Nakagawa, Ken; Okumura, Sakae // PLoS ONE;8/6/2015, Vol. 10 Issue 8, p1 

    Background: Left upper division segmentectomy is one of the major pulmonary procedures; however, it is sometimes difficult to completely dissect interlobar lymph nodes. We attempted to clarify the prognostic importance of hilar and mediastinal nodes, especially of interlobar lymph nodes, in...

  • A Panel of Genetic Polymorphism for the Prediction of Prognosis in Patients with Early Stage Non-Small Cell Lung Cancer after Surgical Resection. Lee, Shin Yup; Choi, Jin Eun; Jeon, Hyo-Sung; Choi, Yi-Young; Lee, Won Kee; Lee, Eung Bae; Lee, Hyun Cheol; Kang, Hyo-Gyoung; Yoo, Seung Soo; Lee, Jaehee; Cha, Seung Ick; Kim, Chang Ho; Lee, Myung Hoon; Kim, Young Tae; Jheon, Sanghoon; Park, Jae Yong // PLoS ONE;10/13/2015, Vol. 10 Issue 10, p1 

    Background: This study was conducted to investigate whether a panel of eight genetic polymorphisms can predict the prognosis of patients with early stage non-small cell lung cancer (NSCLC) after surgical resection. Materials and Methods: We selected eight single nucleotide polymorphisms (SNPs)...

  • Pulmonary Metastases from NSCLC and MPLC (Multiple Primary Lung Cancers): Management and Outcome in a Single Centre Experience. Stella, Franco; Luciano, Giulia; Dell’Amore, Andrea; Greco, Domenico; Ammari, Chadi; Giunta, Domenica; Bini, Alessandro; Dell'Amore, Andrea // Heart, Lung & Circulation;Feb2016, Vol. 25 Issue 2, p191 

    Background: This is an institutional review of surgical management of second pulmonary tumours in patients with history of Non-small Cell Lung Cancer (NSCLC) resection according to The American College of Chest Physicians' (ACCP) revision to the Martini and Melamed's criteria for...

  • Thoracic staging of non-small-cell lung cancer using integrated F-FDG PET/MR imaging: diagnostic value of different MR sequences. Schaarschmidt, Benedikt; Buchbender, Christian; Gomez, Benedikt; Rubbert, Christian; Hild, Florian; Köhler, Jens; Grueneisen, Johannes; Reis, Henning; Ruhlmann, Verena; Wetter, Axel; Quick, Harald; Antoch, Gerald; Heusch, Philipp // European Journal of Nuclear Medicine & Molecular Imaging;Jul2015, Vol. 42 Issue 8, p1257 

    Purpose: To compare the accuracy of different MR sequences in simultaneous PET/MR imaging for T staging in non-small-cell lung cancer in relation to histopathology. Methods: The study included 28 patients who underwent dedicated thoracic PET/MR imaging before tumour resection. Local tumour...

  • Controversies regarding T status and N status for non-small cell lung cancer. Yanli Mo; Jiayin Peng; Wenmei Su; Xinggui Chen; Aibing Wu; Jinmei Li; Zhixiong Yang // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 7, p11675 

    According to the newest version of NCCN Clinical Practice Guidelines for Non-Small Cell Lung Cancer (NSCLC), increasing attentions are paid to the role of nodal status and other high-risk factors, including vascular invasion, wedge resection, tumors > 4 cm, visceral pleural involvement, and...

  • Significant correlation between urinary N¹, N12-diacetylspermine and tumor invasiveness in patients with clinical stage IA non-small cell lung cancer. Yusuke Takahashi; Hirotoshi Horio; Koji Sakaguchi; Kyoko Hiramatsu; Masao Kawakita // BMC Cancer;2015, Vol. 15 Issue 1, p1 

    Background: To select optimal candidates for limited lung resection, it is necessary to accurately differentiate the non-invasive tumors from other small-sized lung cancer. Urinary N¹, N12-diacetylspermine (DiAcSpm) has been reported to be a useful tumor marker for various cancers. We aimed...

  • Strategies for clinical implementation of TNM-Immunoscore in resected nonsmall-cell lung cancer. Donnem, T.; Kilvaer, T. K.; Andersen, S.; Richardsen, E.; Paulsen, E. E.; Hald, S. M.; Al-Saad, S.; Brustugun, O. T.; Helland, A.; Lund-Iversen, M.; Solberg, S.; Gronberg, B. H.; Wahl, S. G. F.; Helgeland, L.; Fløtten, O.; Pohl, M.; Al-Shibli, K.; Sandanger, T. M.; Pezzella, F.; Busund, L. T. // Annals of Oncology;Feb2016, Vol. 27 Issue 2, p225 

    Immunoscore is a prognostic tool defined to quantify in situ immune cell infiltrates and appears highly promising as a supplement to the tumor-node-metastasis (TNM) classification of various tumors. In colorectal cancer, an international task force has initiated prospective multicenter studies...

  • Lymph node ratio as a prognostic factor in patients with pathological N2 non-small cell lung cancer. Masaya Tamura; Isao Matsumoto; Daisuke Saito; Shuhei Yoshida; Munehisa Takata; Hirofumi Takemura // World Journal of Surgical Oncology;11/25/2016, Vol. 14, p1 

    Background: The aim of this study was to investigate whether the lymph node ratio (LNR) was associated with the prognosis of patients, who underwent surgery for pathological N2 non-small cell lung cancer (NSCLC). Methods: A total of 182 patients were diagnosed with pathological N2 disease and...

  • Contribution of Mediastinoscopy in the Preoperative Staging of Non-Small Cell Lung Cancer. Achour, Karima // Pan Arab Journal of Oncology;Jun2016, Vol. 9 Issue 2, p29 

    Aim: The Mediastinoscopy is an endoscopic examination of the mediastinum, to make biopsies particularly at the level of some lymph nodes areas. The absence in our center of mini invasive explorations make a diagnostic weapon of choice in the diagnosis of mediastinal lymph node invasion in lung...

  • Validating margin status in lung wedge resection for clinical stage I non-small cell lung cancer. Sawabata, Noriyoshi; Kawase, Akikazu; Takahashi, Nobumasa; Kawaguchi, Takeshi; Woo, Tetsukan; Saito, Yuichi; Shiono, Satoshi; Matsutani, Noriyuki; From The International Lung-Clinical-Study Organization (ILO) // Surgery Today;Oct2018, Vol. 48 Issue 10, p963 

    Stage I non-small cell lung cancer (NSCLC) is a localized disease without metastasis; therefore, it can be treated effectively with local therapies. Pulmonary resection is the most frequent treatment, performed as pulmonary wedge resection, segmentectomy, lobectomy, or pneumonectomy. Some...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics