TITLE

CFTR pharmacology

AUTHOR(S)
Zegarra-Moran, Olga; Galietta, Luis
PUB. DATE
January 2017
SOURCE
Cellular & Molecular Life Sciences;Jan2017, Vol. 74 Issue 1, p117
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
CFTR protein is an ion channel regulated by cAMP-dependent phosphorylation and expressed in many types of epithelial cells. CFTR-mediated chloride and bicarbonate secretion play an important role in the respiratory and gastrointestinal systems. Pharmacological modulators of CFTR represent promising drugs for a variety of diseases. In particular, correctors and potentiators may restore the activity of CFTR in cystic fibrosis patients. Potentiators are also potentially useful to improve mucociliary clearance in patients with chronic obstructive pulmonary disease. On the other hand, CFTR inhibitors may be useful to block fluid and electrolyte loss in secretory diarrhea and slow down the progression of polycystic kidney disease.
ACCESSION #
120530591

 

Share

Other Topics