TITLE

Zebrafish as a Vertebrate Model System to Evaluate Effects of Environmental Toxicants on Cardiac Development and Function

AUTHOR(S)
Sarmah, Swapnalee; Marrs, James A.
PUB. DATE
December 2016
SOURCE
International Journal of Molecular Sciences;Dec2016, Vol. 17 Issue 12, p2123
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Environmental pollution is a serious problem of the modern world that possesses a major threat to public health. Exposure to environmental pollutants during embryonic development is particularly risky. Although many pollutants have been verified as potential toxicants, there are new chemicals in the environment that need assessment. Heart development is an extremely sensitive process, which can be affected by environmentally toxic molecule exposure during embryonic development. Congenital heart defects are the most common life-threatening global health problems, and the etiology is mostly unknown. The zebrafish has emerged as an invaluable model to examine substance toxicity on vertebrate development, particularly on cardiac development. The zebrafish offers numerous advantages for toxicology research not found in other model systems. Many laboratories have used the zebrafish to study the effects of widespread chemicals in the environment on heart development, including pesticides, nanoparticles, and various organic pollutants. Here, we review the uses of the zebrafish in examining effects of exposure to external molecules during embryonic development in causing cardiac defects, including chemicals ubiquitous in the environment and illicit drugs. Known or potential mechanisms of toxicity and how zebrafish research can be used to provide mechanistic understanding of cardiac defects are discussed.
ACCESSION #
120516947

 

Related Articles

  • Disruption of the folate pathway in zebrafish causes developmental defects. Lee, Marina S.; Bonner, Jenna R.; Bernard, David J.; Sanchez, Erica L.; Sause, Eric T.; Prentice, R. Reid; Burgess, Shawn M.; Brody, Lawrence C. // BMC Developmental Biology;2012, Vol. 12 Issue 1, p12 

    Background: Folic acid supplementation reduces the risk of neural tube defects and congenital heart defects. The biological mechanisms through which folate prevents birth defects are not well understood. We explore the use of zebrafish as a model system to investigate the role of folate...

  • An Exploratory Analysis of Stream Teratogenicity and Human Health Using Zebrafish Whole-Sediment Toxicity Test. Dellinger, Matthew; Carvan, Michael J.; Klingler, Rebekah H.; McGraw, Joseph E.; Ehlinger, Timothy // Challenges (20781547);2014, Vol. 5 Issue 1, p75 

    This study demonstrates a novel application of effect-based toxicity testing for streams that may provide indications of co-perturbation to ecological and human health. For this study, a sediment contact assay using zebrafish (Danio rerio) embryos was adapted to serve as an indicator of...

  • MicroRNA 218 Mediates the Effects of Tbx5a Over-Expression on Zebrafish Heart Development. Chiavacci, Elena; Dolfi, Luca; Verduci, Lorena; Meghini, Francesco; Gestri, Gaia; Evangelista, Alberto Mercatanti Monica; Wilson, Stephen W.; Cremisi, Federico; Pitto, Letizia // PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1 

    tbx5, a member of the T-box gene family, encodes one of the key transcription factors mediating vertebrate heart development. Tbx5 function in heart development appears to be exquisitely sensitive to gene dosage, since both haploinsufficiency and gene duplication generate the cardiac...

  • Acute toxicity and histopathological effects of naproxen in zebrafish ( Danio rerio) early life stages. Li, Qian; Wang, Peipei; Chen, Ling; Gao, Hongwen; Wu, Lingling // Environmental Science & Pollution Research;Sep2016, Vol. 23 Issue 18, p18832 

    Zebrafish ( Danio rerio) embryos and larvae were selected to investigate the potential risk and aquatic toxicity of a widely used pharmaceutical, naproxen. The acute toxicity of naproxen to embryos and larvae was measured, respectively. The histopathology was investigated in the liver of...

  • The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous... Hatta, K.; Kimmel, C.B. // Nature;3/28/1991, Vol. 350 Issue 6316, p339 

    Analyzes mutations in the zebrafish. Reports that in wild-type embryos the floor plate develops as a simply organized single cell row, but that its development fails in embryos bearing the newly discovered zygotic lethal cyclops mutation, `cyc'-1(b16).

  • A homeobox gene essential for zebrafish notochord development. Talbot, William S.; Trevarrow, Bill // Nature;11/9/1995, Vol. 378 Issue 6553, p150 

    Describes the phenotype of floating head mutant zebrafish embryos. Absence of notochord; Display of abnormalities in mesoderm and CNS derivatives; Molecular characterization of the floating head gene.

  • A zebra in the classroom. Leake, Devin; Morvillo, Nancy // American Biology Teacher (National Association of Biology Teache;Jan1998, Vol. 60 Issue 1, p32 

    Presents information relating to the care and breeding of zebrafish by biology students. Instructions for breeding of the fish; Development of the zebrafish embryos; Steps for regeneration process of the fish.

  • Effect of Intermittent Chlorination on Developing Zebrafish Embryos (Brachydanio rerio) Cohen, G. M.; Yosha, S. F. // Bulletin of Environmental Contamination & Toxicology;Mar1979, Vol. 21 Issue 4/5, p703 

    No abstract available.

  • MYOCARDIAL WALL MOTION IN ZEBRAFISH EMBRYOS ASSESSED BY VIDEO EDGE DETECTION: INFLUENCE OF NOREPINEPHRINE, MS-222 AND TEMPERATURE.  // Heart;Jul2008 Supp, Vol. 94, pA53 

    Presents an abstract to the article "Myocardial Wall Motion in Zebrafish Embryos Assessed by Video edge Detection: Influence of Norepinephrine, MS-222 and Temperature," by C. S. Tucker, J. J. Mullins, and M. A. Denvir.

  • From the Editor-in-Chief. Baker, Edward // Cardiology in the Young;Feb2008, Vol. 18 Issue 1, p1 

    The article discusses various reports published within the issue, including one on congenital heart disease and another on angioplasty.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics