p53 as a Regulator of Lipid Metabolism in Cancer

Parrales, Alejandro; Tomoo Iwakuma
December 2016
International Journal of Molecular Sciences;Dec2016, Vol. 17 Issue 12, p2074
Academic Journal
Enhanced proliferation and survival are common features of cancer cells. Cancer cells are metabolically reprogrammed which aids in their survival in nutrient-poor environments. Indeed, changes in metabolism of glucose and glutamine are essential for tumor progression. Thus, metabolic reprogramming is now well accepted as a hallmark of cancer. Recent findings suggest that reprogramming of lipid metabolism also occurs in cancer cells, since lipids are used for biosynthesis of membranes, post-translational modifications, second messengers for signal transduction, and as a source of energy during nutrient deprivation. The tumor suppressor p53 is a transcription factor that controls the expression of proteins involved in cell cycle arrest, DNA repair, apoptosis, and senescence. p53 also regulates cellular metabolism, which appears to play a key role in its tumor suppressive activities. In this review article, we summarize non-canonical functions of wild-type and mutant p53 on lipid metabolism and discuss their association with cancer progression.


Related Articles

  • Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Bissell, Mina J.; Hines, William C. // Nature Medicine;Mar2011, Vol. 17 Issue 3, p320 

    Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as 'occult cancer'. We...

  • PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression. Lee, Y.; Kim, S. J.; Park, H. D.; Park, E. H.; Huang, S. M.; Jeon, S. B.; Kim, J.-M.; Lim, D.-S.; Koh, S. S. // Oncogene;1/7/2010, Vol. 29 Issue 1, p56 

    Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the...

  • MYC suppresses cancer metastasis by direct transcriptional silencing of ?v and ?3 integrin subunits. Liu, Hong; Radisky, Derek C.; Yang, Dun; Xu, Ren; Radisky, Evette S.; Bissell, Mina J.; Bishop, J. Michael // Nature Cell Biology;Jun2012, Vol. 14 Issue 6, p567 

    Overexpression of MYC transforms cells in culture, elicits malignant tumours in experimental animals and is found in many human tumours. We now report the paradoxical finding that this powerful oncogene can also act as a suppressor of cell motility, invasiveness and metastasis. Overexpression of...

  • Suppression of tumor and metastasis progression through the scaffolding functions of SSeCKS/Gravin/AKAP12. Gelman, Irwin // Cancer & Metastasis Reviews;Dec2012, Vol. 31 Issue 3/4, p493 

    Scaffolding proteins such as SSeCKS/Gravin/AKAP12 ('AKAP12') are thought to control oncogenic signaling pathways by regulating key mediators in a spatiotemporal manner. The downregulation of AKAP12 in many human cancers, often associated with promoter hypermethylation, or the loss of its locus...

  • Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells. Zaric, J; Joseph, J-M; Tercier, S; Sengstag, T; Ponsonnet, L; Delorenzi, M; Rüegg, C // Oncogene;1/5/2012, Vol. 31 Issue 1, p48 

    Cyclooxyganase-2 (COX-2), a rate-limiting enzyme in the prostaglandin synthesis pathway, is overexpressed in many cancers and contributes to cancer progression through tumor cell-autonomous and paracrine effects. Regular use of non-steroidal anti-inflammatory drugs or selective COX-2 inhibitors...

  • Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion. Mehta, S. A.; Christopherson, K. W.; Bhat-Nakshatri, P.; Goulet, R. J.; Broxmeyer, H. E.; Kopelovich, L.; Nakshatri, H. // Oncogene;5/17/2007, Vol. 26 Issue 23, p3329 

    Chemokine receptor CXCR4 and its ligand CXCL12 are suggested to be involved in migration, invasion and metastasis of breast cancer cells. Mutation of the tumor suppressor gene p53 in breast cancer is associated with metastasis and aggressive clinical phenotype. In this report, we demonstrate...

  • Association between cytosolic expression of BRCA1 and metastatic risk in breast cancer. Santivasi, W L; Wang, H; Wang, T; Yang, Q; Mo, X; Brogi, E; Haffty, B G; Chakravarthy, A B; Xia, Fen // British Journal of Cancer;7/28/2015, Vol. 113 Issue 3, p453 

    Background:Although BRCA1 has been extensively studied for its role as a tumour-suppressor protein, the role of BRCA1 subcellular localisation in oncogenesis and tumour progression has remained unclear. This study explores the impact of BRCA1 mislocalisation on clinical outcomes in breast...

  • The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance. Fei Xie; Lin Ye; Jinfeng Chen; Nan Wu; Zhiqian Zhang; Yue Yang; Lijian Zhang; Jiang, Wen G. // Journal of Translational Medicine;2010 Supplement 1, Vol. 9 Issue Suppl 1, p95 

    Background: Metastasis suppressor-1 (MTSS1) has been proposed to function as a cytoskeletal protein with a role in cancer metastasis. Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers, yet the clinical relevance of MTSS1 in oesophageal squamous cell...

  • Alternative splicing in cancer: implications for biology and therapy. Chen, J; Weiss, W A // Oncogene;1/2/2015, Vol. 34 Issue 1, p1 

    Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts, can lead to loss-of-function in tumor suppressors or activation of oncogenes and cancer pathways....

  • Mutant p53--associated myosin-X upregulation promotes breast cancer invasion and metastasis. Arjonen, Antti; Kaukonen, Riina; Mattila, Elina; Rouhi, Pegah; Högnäs, Gunilla; Harri Sihto; Miller, Bryan W.; Morton, Jennifer P.; Bucher, Elmar; Taimen, Pekka; Virtakoivu, Reetta; Yihai Cao; Sansom, Owen J.; Joensuu, Heikki; Ivaska, Johanna // Journal of Clinical Investigation;Mar2014, Vol. 124 Issue 3, p1069 

    Mutations of the tumor suppressor TP53 are present in many forms of human cancer and are associated with increased tumor cell invasion and metastasis. Several mechanisms have been identified for promoting dissemination of cancer cells with TP53 mutations, including increased targeting of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics