Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Infammatory Skin Diseases

Youn Kyung Houh; Kyung Eun Kim; Hyun Jeong Park; Daeho Cho
December 2016
International Journal of Molecular Sciences;Dec2016, Vol. 17 Issue 12, p2059
Academic Journal
Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.


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