TITLE

The Emergence of the Dose--Response Concept in Biology and Medicine

AUTHOR(S)
Calabrese, Edward J.
PUB. DATE
December 2016
SOURCE
International Journal of Molecular Sciences;Dec2016, Vol. 17 Issue 12, p2034
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A historical assessment of the origin of the dose-response in modern toxicology and its integration as a central concept in biology and medicine is presented. This article provides an overview of how the threshold, linear and biphasic (i.e., hormetic) dose-response models emerged in the late 19th and early 20th centuries and competed for acceptance and dominance. Particular attention is directed to the hormetic model for which a general description and evaluation is provided, including its historical basis, and how it was marginalized by the medical and pharmacology communities in the early decades of the 20th century.
ACCESSION #
120516858

 

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