TITLE

Exosomes as miRNA Carriers: Formation--Function--Future

AUTHOR(S)
Xiaojie Yu; Odenthal, Margarete; Fries, Jochen W. U.
PUB. DATE
December 2016
SOURCE
International Journal of Molecular Sciences;Dec2016, Vol. 17 Issue 12, p2028
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing understanding of exosomes' formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine.
ACCESSION #
120516852

 

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