TITLE

Prolactin: Friend or Foe in Central Nervous System Autoimmune Inflammation?

AUTHOR(S)
Costanza, Massimo; Pedotti, Rosetta
PUB. DATE
December 2016
SOURCE
International Journal of Molecular Sciences;Dec2016, Vol. 17 Issue 12, p2026
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The higher prevalence of multiple sclerosis (MS) in females, along with the modulation of disease activity observed during pregnancy and the post-partum period, has suggested a hormonal influence in MS. Even if prolactin (PRL) does not belong to the sex hormones family, its crucial role in female reproduction and lactation has prompted great efforts to understand if PRL could represent a gender factor in the pathogenesis of MS and experimental autoimmune encephalomyelitis (EAE), the animal model for this disease. Extensive literature has documented a remarkable immune-stimulating potential for this hormone, indicating PRL as a disease-promoting factor in MS and EAE. However, recent work has pointed out that PRL is endowed with important neuroprotective and remyelinating properties and has encouraged a reinterpretation of the involvement of this hormone in MS. In this review we summarize both the protective functions that PRL exerts in central nervous system tissue as well as the inflammatory activity of this hormone in the context of autoimmune responses against myelin. Last, we draw future lines of research that might help to better clarify the impact of PRL on MS pathology.
ACCESSION #
120516850

 

Related Articles

  • Do serum levels of prolactin correlate with age in multiple sclerosis?  // Canadian Journal of Neurological Sciences;May2003 Supplement 2, Vol. 30, pS62 

    Presents an abstract of the study 'Do Serum Levels of Prolactin Correlate With Age in Multiple Sclerosis?' submitted to the 38th meeting of the Canadian Congress of Neurological Sciences.

  • New clue to MS relapses.  // Inside MS;Apr/May2007, Vol. 25 Issue 2, p30 

    The article discusses the findings of a study on the role of a protein called osteopontin in multiple sclerosis (MS) relapses. Researchers from Stanford University carried out the study on mice with different MS-like diseases. Some of the mice had been engineered to lack osteopontin. In a series...

  • The translation of drug efficacy from in vivo models to human disease with special reference to experimental autoimmune encephalomyelitis and multiple sclerosis. Bolton, C. // Inflammopharmacology;Oct2007, Vol. 15 Issue 5, p183 

    The search for new drugs to treat human disease is strongly reliant on the use of in vivo animal models to generate pre-clinical data. However, drug efficacy in experimental disease models does not often translate effectively to the human condition. Multiple sclerosis (MS) is a disease of the...

  • Acamprosate modulates experimental autoimmune encephalomyelitis. Sternberg, Z.; Cesario, A.; Rittenhouse-Olson, K.; Sobel, R.; Pankewycz, O.; Zhu, B.; Whitcomb, T.; Sternberg, D.; Munschauer, F. // Inflammopharmacology;Feb2012, Vol. 20 Issue 1, p39 

    Objective: This pilot study aimed to determine the efficacy of acamprosate ( N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). Background: The amino acid taurine has multiple...

  • Current immunotherapy in multiple sclerosis. BASHIR, KHURRAM; WHITAKER, JOHN N; Whitaker, John N // Immunology & Cell Biology;Feb1998, Vol. 76 Issue 1, p55 

    The underlying pathophysiology of multiple sclerosis is presumed to be autoimmune in nature. Attempts to find an effective treatment for this common disease of the central nervous system have primarily focused on immune-mediated therapies, both immunosuppressive and immunomodulatory. The wide...

  • Therapeutic value of serum uric acid levels increasing in the treatment of multiple sclerosis. TonĨev, Goran // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Oct2006, Vol. 63 Issue 10, p879 

    Background/Aim. Uric acid was successfully used in both, prevention and treatment of the animal model of multiple sclerosis (MS). Recently it has been shown that inosine, a ribosylated precursor of uric acid, might be used to elevate serum uric acid levels in MS patients. The aim of this study...

  • Astrocytes in multiple sclerosis: A product of their environment. Nair, A.; Frederick, T. J.; Miller, S. D. // Cellular & Molecular Life Sciences;Sep2008, Vol. 65 Issue 17, p2702 

    It has long been thought that astrocytes, like other glial cells, simply provide a support mechanism for neuronal function in the healthy and inflamed central nervous system (CNS). However, recent evidence suggests that astrocytes play an active and dual role in CNS inflammatory diseases such as...

  • Multiple sclerosis gets a shot in the arm. S. G. // Alive: Canada's Natural Health & Wellness Magazine;Feb2007, Issue 292, p52 

    The article presents an early research from the Children's Hospital in Boston, Massachusetts which highlights the potential benefits of a nicotinamide for people with multiple sclerosis (MS). The study showed that nicotinamide protects brain cells from degeneration in mice with an MS-like...

  • Induction of inhibitory central nervous system-derived and stimulatory blood-derived dendritic cells suggests a dual role for granulocyte-macrophage colony-stimulating factor in central nervous system inflammation. Hesske, Lysann; Vincenzetti, Christine; Heikenwalder, Mathias; Prinz, Marco; Reith, Walter; Fontana, Adriano; Suter, Tobias // Brain: A Journal of Neurology;Jun2010, Vol. 133 Issue 6, p1637 

    The mononuclear phagocyte system, particularly dendritic cells, plays several pivotal roles in the development of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Here, we demonstrate that functionally distinct dendritic cell subpopulations are present in the...

  • Minocycline delays but does not attenuate the course of experimental autoimmune encephalomyelitis in Streptococcus pneumoniae-infected mice. Isabel Herrmann; Markus Kellert; Annette Spreer; Joachim Gerber; Helmut Eiffert; Marco Prinz; Roland Nau // Journal of Antimicrobial Chemotherapy (JAC);Jan2007, Vol. 59 Issue 1, p74 

    Objectives: Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), can be aggravated by a mild Streptococcus pneumoniae infection. This study was performed to assess whether treatment with antibiotics inhibiting bacterial protein synthesis reduces the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics