TITLE

Evidence of Bioactive Compounds from Vernonia polyanthes Leaves with Topical Anti-Inflammatory Potential

AUTHOR(S)
Rodrigues, Kamilla C. M.; Chibli, Lucas A.; Santos, Bruna C. S.; Temponi, Vanessa S.; Pinto, Nícolas C. C.; Scio, Elita; Del-Vechio-Vieira, Glauciemar; Alves, Maria S.; Sousa, Orlando V.
PUB. DATE
December 2016
SOURCE
International Journal of Molecular Sciences;Dec2016, Vol. 17 Issue 12, p1929
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Vernonia polyanthes Less. (Asteraceae), popularly known as "assa-peixe", is a plant species used in Brazilian traditional medicine for the treatment of cutaneous damage, cicatrization, inflammation, and rheumatism. Based on these ethnopharmacological findings, the current study evaluated the topical anti-inflammatory effects of the hexane (HEVP) and ethyl acetate (EAEVP) extracts from V. polyanthes leaves in experimental models of skin inflammation. Chemical characterization was carried out by HPLC-UV/DAD analysis. Anti-inflammatory activity was evaluated using Croton oil-, arachidonic acid (AA)-, phenol-, ethyl phenylpropiolate (EPP)-, and capsaicin-induced ear edema models in mice. Histopathological evaluation and measurements of myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) enzymes were also performed. Rutin, luteolin, and apigenin were identified in EAEVP. Topically applied HEVP and EAEVP significantly (p < 0.05, p < 0.01 or p < 0.001) reduced edema induced by five different irritants at the doses tested (0.1, 0.5 and 1.0 mg/ear). Histopathological analysis revealed a reduction of edema, inflammatory cell infiltration, and vasodilation. In addition, the enzymes activity (MPO and NAG) in the ear tissues was reduced by the topical treatment of HEVP and EAEVP (p < 0.05, p < 0.01 or p < 0.001). The results suggest that V. polyanthes leaves are effective against cutaneous damage, which support its traditional use and open up new possibilities for the treatment of skin disorders.
ACCESSION #
120516785

 

Related Articles

  • IN VITRO ANTIMALARIAL ACTIVITY OF THE EXTRACTS OF Vernonia amygdalina COMMONLY USED IN TRADITIONAL MEDICINE IN NIGERIA. Sha'a, K. K; Oguche, S .; Watila, I. M.; Ikpa, T. F. // Science World Journal;Jun2011, Vol. 6 Issue 2, p5 

    Malaria is one of the most important of infectious diseases in the tropics and sub-tropics. The search for antimalarial compounds has been necessitated by P. falciparum resistance to almost all antimalarial drugs. In this study, the in vitro antimalarial activities of the aqueous and ethanolic...

  • TRICHILIA MONADELPHA BARK EXTRACTS INHIBIT CARRAGEENAN-INDUCED FOOT-OEDEMA IN THE 7-DAY OLD CHICK AND THE OEDEMA ASSOCIATED WITH ADJUVANT-INDUCED ARTHRITIS IN RATS. Ainooson1, G. K.; Owusu1, G.; Woode1, E.; Ansah, C.; Annan, K. // African Journal of Traditional, Complementary & Alternative Medi;Jan2012, Vol. 9 Issue 1, p8 

    Trichilia monadelpha (Thonn) JJ De Wilde (Meliaceae) bark extract is used in African traditional medicine for the management of various disease conditions including inflammatory disorders such as arthritis. The present study was undertaken to evaluate the anti-inflammatory properties of aqueous...

  • Evaluation of anti-inflammatory activity of the leaf extract of Wrightia tomentosa. Roem & Schult. David, E.; Elumalai, E. K.; Therasa, S. Viviyan; Thirumalai, T. // Journal of Pharmacy Research;Feb2010, Vol. 3 Issue 2, p208 

    The methanol: dichloromethane (1:1) extract of the leaves of Wrightia tomentosa (Family: Apocynaceae), a traditional medicine plant was tested for anti-inflammatory activity dextran induced paw edema in rats. The results revealed that methanol: dichloromethane extract significantly ameliorate...

  • Anti-nociceptive and anti-inflammatory activities of extract of Anchomanes difformis in rats. Humphrey Adebayo, Abiodun; John-Africa, Lucy Binda; Agbafor, Amarachi Grace; Omotosho, Omolola Elizabeth; Olusoji Mosaku, Timothy // Pakistan Journal of Pharmaceutical Sciences;Mar2014, Vol. 27 Issue 2, p265 

    Anchomanes difformis is a tropical plant that has been used in folklore to treat diverse complications. The leaf extract of A. difformis was investigated for possible anti-nociceptive and anti-inflammatory effects in albino wistar rats. In these independent studies, two sets of twenty five rats...

  • Evaluation of Analgesic and Anti-Inflammatory Activity of Kalanchoe spanthulata Leaves Extract. Sharma, Neeraj K.; Priyanka; Jha, K. K. // Journal of Advanced Scientific Research;Nov2011, Vol. 2 Issue 4, p71 

    With many of kalanchoe's traditional uses verified by animal research, it is not unusual that it continues to be a popular natural remedy throughout the tropics where it grows. In the present investigation anti-inflammatory and analgesic profile of Kalanchoe spanthulata has been explored using...

  • Analgesic and Anti-inflammatory Profile of n-Hexane Fraction of Viola betonicifolia. Muhammad, Naveed; Saeed, Muhammad; Gilani, Syed Naeemuddin; Haq, Ikram ul; Khan, Haroon // Tropical Journal of Pharmaceutical Research;Dec2012, Vol. 11 Issue 6, p963 

    Purpose: To evaluate the analgesic and anti-inflammatory activities of n-hexane extract of the whole plant of Viola betonicifolia Sm, family: Violaceace. Methods: The n-hexane fraction of Viola betonicifolia (VBHF) was tested for its analgesic and antiinflammatory activities (carrageenan-induced...

  • Evaluation of Anti-Inflammatory and Anti-pyretic activity of total alcoholic extract of Croton sparsiflorus and its fractions. Kumar, Jain Amit; Sharma, Paras; Sikarwar, Mukesh S. // Journal of Pharmacy Research;May2010, Vol. 3 Issue 5, p1149 

    Croton Sparsiflorus Morong (Family: Euphorbiaceae) is commonly used in traditional system of medicine for the treatment of inflammation, pain, jaundice, rheumatism, arthritis, anemia, etc.In the present study, anti-inflammatory and antipyretic effect of total ethanolic extract of whole plant of...

  • Study of the Anti-Inflammatory Activity of Flavonic Extract of Globularia alypum L. BOUTEMAK, K.; SAFTA, B.; AYACHI, N. // Acta Physica Polonica, A.;Aug2015, Vol. 128 Issue 2B, pB-239 

    Globularia alypum L. of the family Globulariaceae is widely used in traditional medicine for its antiinflammatory activity. The aim of this study is to evaluate the anti-inflammatory activity of flavonic extract (butanol fraction) of globularia alypum against carrageenan induced paw-oedema in...

  • Chemical Constituents and Anti-inflammatory Activities of Inonotus obliquus. ZHANG Xu; ZHAO Fen-qin; HAN Guang; LIU Lei; GAO Xin // Natural Product Research & Development;Jun2010, Vol. 22 Issue 3, p433 

    To study the inflammatory activities of lanostane-type triterpenes in Inonotus obliquus, the extracts of I. obliquus were chromatographed repeatedly to obtain the lanostane-type triterpenes contained. The structures of the compounds were elucidated on the basis of spectroscopic analysis (1H NMR,...

  • Bioassay-Guided Chemical Study of the Anti-Inflammatory Effect of Senna villosa (Miller) H.S. Irwin & Barneby (Leguminosae) in TPA-Induced Ear Edema. Susunaga-Notario, Ana del Carmen; Pérez-Gutiérrez, Salud; Zavala-Sánchez, Miguel Ángel; Almanza-Pérez, Julio Cesar; Gutiérrez-Carrillo, Atilano; Arrieta-Báez, Daniel; López-López, Ana Laura; Román-Ramos, Rubén; Flores-Sáenz, José Luis Eduardo; Alarcón-Aguilar, Francisco Javier // Molecules;Jul2014, Vol. 19 Issue 7, p10261 

    Senna villosa (Miller) is a plant that grows in México. In traditional Mexican medicine, it is used topically to treat skin infections, pustules and eruptions and to heal wounds by scar formation. However, studies of its potential anti-inflammatory effects have not been performed. The aim of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics