A randomized controlled clinical trial of combination therapy for type 2 diabetes by vildagliptin, metformin, and α-glucosidase inhibitor

Wang, Qiong; Su, Yong; Lv, Lifang
December 2016
International Journal of Diabetes in Developing Countries;Dec2016, Vol. 36 Issue 4, p420
Academic Journal
The article provides a study to evaluate the efficacy and safety of vildagliptin combined with metformin and α-glucosidase inhibitors for treatment of type 2 diabetes. The relevant indicators of the patients before and after the test for 12 weeks were detected, from 490 cases of subjects who were in Henan Provincial People's Hospital in China from February 2013 to July 2013.


Related Articles

  • Pharmacy Research at URI: Mining Red Maple (Acer rubrum) Trees for Novel Therapeutics to Manage Diabetes. Seeram, Navindra P.; Xu, Jialin; Li, Liya; Slitt, Angela // Medicine & Health Rhode Island;Sep2012, Vol. 95 Issue 9, p283 

    The article offers information on phenolic-enriched extracts from the bark of Acer rubrum (red maple) for the treatment of Type 2 Diabetes Mellitus(T2DM). It states that a male adult C57BL/6 mice was administered red maple bark extract(MBE) in combination with a bolus sucrose challenge to...

  • Pharmacological Management of Type 2 Diabetes Mellitus: An Update. El-Kaissi, Samer; Sherbeeni, Suphia // Current Diabetes Reviews;Nov2011, Vol. 7 Issue 6, p392 

    While lifestyle modifications and metformin are the cornerstone of the initial management of type 2 diabetes mellitus, there is an increasing array of second and third-line pharmacological agents for this condition. These include sulphonylureas, insulin, thiazolidinediones and alpha-glucosidase...

  • Molecular Docking and Inhibition Kinetics of α-glucosidase Activity by Labdane Diterpenes Isolated from Tora Seeds ( Alpinia nigra B.L. Burtt.). Ghosh, Sudipta; Rangan, Latha // Applied Biochemistry & Biotechnology;Feb2015, Vol. 175 Issue 3, p1477 

    Current approach against type 2 diabetes involves α-glucosidase inhibitors like acarbose associated with many side effects. Therefore, as an alternative to the existing drug, many natural products mainly from plant sources have been investigated which inhibit α-glucosidase. Here, we have...

  • Effectiveness and safety of fixed dose combination of acarbose/metformin in Indian Type 2 diabetes patients: Results from observational GLOBE Study. Saboo, Banshi; Reddy, Gundam Chandrasekhara; Juneja, Subhashchander; Kedia, Ashok Kumar; Manjrekar, Pravin; Rathod, Rahul // Indian Journal of Endocrinology & Metabolism;Jan/Feb2015, Vol. 19 Issue 1, p129 

    Primary objective - evaluate effectiveness and safety of acarbose/metformin fixed dose FDC on glycemic control in Indian T2DM patients in real life clinical setting. Secondary objective - evaluate safety and satisfaction of treatment. Materials and Methods: Open-label, prospective, multicentre,...

  • ADVANTAGE OF PRANDIAL INSULIN AS A THERAPEUTIC APPROACH IN INITIAL SECONDARY PANCREATIC β-CELL EXHAUSTION IN TYPE 2 DIABETIC PATIENTS. Kokić, Slaven; Kokić, Višnja; Krnić, Mladen; Mirić, Lina; Jovanović, Željko; Orlić-Crnčević, Željka // Diabetologia Croatica;2010, Vol. 39 Issue 1, p37 

    The aim of this study was to compare prandial insulin therapy with standard therapeutic options available at that time (2000-2005). Two hundred and thirty seven type 2 diabetic patients were randomly selected and divided equally into three treatment groups: glimepiride + metformin + acarbose (3...

  • Effects of L-Malic Acid on Alpha-Glucosidase: Inhibition Kinetics and Computational Molecular Dynamics Simulations. Gou, Lin; Zhan, Yi; Lee, Jinhyuk; Li, Xuan; Lü, Zhi-Rong; Zhou, Hai-Meng; Lu, Hang; Wang, Xi-Yao; Park, Yong-Doo; Yang, Jun-Mo // Applied Biochemistry & Biotechnology;Feb2015, Vol. 175 Issue 4, p2232 

    The inhibitory effect of L-malic acid (MA) on alpha-glucosidase (EC was investigated by combination study between inhibition kinetics and computational simulations. The results from the serial kinetics demonstrated that MA could directly inactivate the enzyme activity in a...

  • 9. Glucose control: Non-insulin therapies.  // Journal of Endocrinology, Metabolism & Diabetes of South Africa;Jun2012, Vol. 17 Issue 2, pS23 

    The article discusses the use of non-insulin-based therapies in managing type 2 diabetes. It offers information on several oral agents developed to delay and avoid insulin therapy including metformin, sulphonylureas, alpha glucosidase inhibitors, and incretins. Also explored are the mechanisms...

  • Intensive and standard glucose control did not differ for CV events or death in poorly controlled type 2 diabetes. Booth, Gillian L. // Evidence Based Medicine;Jun2009, Vol. 14 Issue 3, p7 

    The article presents a randomised controlled trial which investigates the effectiveness of intensive and standard glucose control in controlling death to patients with type 2 diabetes. It notes that the study was conducted in 20 sites in the U.S. Result shows that oral metformin plus...

  • Enhancing macrovascular outcomes in DM2. Kuritzky, Louis // Primary Care Reports;Aug2009 Supplement, p15 

    The article discusses research on the effects of various treatments in patients with type 2 diabetes mellitus (DM2). It references a study by the BARi 2D Study Group titled "A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease," published in a 2009 issue of the "New...

  • High and typical 18F-FDG bowel uptake in patients treated with metformin. Gontier, Eric; Fourme, Emmanuelle; Wartski, Myriam; Blondet, Cyrille; Bonardel, Gerald; Stanc, Elise Le; Mantzarides, Marina; Foehrenbach, Herve; Pecking, Alain-Paul; Alberini, Jean-Louis // European Journal of Nuclear Medicine & Molecular Imaging;Jan2008, Vol. 35 Issue 1, p95 

    This prospective and bi-centric study was conducted in order to determine the impact of antidiabetic treatments (AD) on 18F-FDG bowel uptake in type 2 diabetic patients. Fifty-five patients with previously diagnosed and treated type 2 diabetes mellitus (group 1) were divided in two subgroups: AD...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics